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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Protective Effects of Picorrhiza Kurroa Extract against 2-Acetylaminofluorene-Induced Hepatotoxicity in Wistar Rats

Volume 26, Issue 3, 2007, pp. 195-205
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i3.40
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ABSTRACT

Picrorrhiza kurroa has been shown to impart significant hepatoprotective activities, partly by modulation of free radical—induced lipid peroxidation. Lipid peroxidation and reactive oxygen species are associated with hepatic injury. The effect of P. kurroa treatment on the antiproliferative response and, hepatic antioxidant enzymes of rats administered with 2-acetylaminofluorene (2-AAF) was studied in Wistar rats. 2-AAF (50 mg/kg body weight, i.p.) enhances hepatic lipid peroxidation, with reduction in hepatic glutathione content, glutathione peroxidase, glutathione reductase, catalase, and glutathione-s-transferase. There was an increase in the levels of transa-minase enzymes and LDH. 2-AAF treatment also enhanced ornithine decarboxylase (ODC) activity and [3H] thymidine incorporation into hepatic DNA. Pretreatment of rats orally with P. kurroa extract (250 and 500 mg/kg body weight) resulted in significant decrease in lipid peroxidation, transaminase enzymes, LDH, hepatic ODC activity, and DNA synthesis (p < 0.001). Hepatic glutathione content (p < 0.001), glutathione metabolizing enzymes (p < 0.001), and antioxidant enzymes were also recovered to significant level (p < 0.001).

CITED BY
  1. Babiker Fawzi, Al-Kouh Aisha, Kilarkaje Narayana, Lead exposure induces oxidative stress, apoptosis, and attenuates protection of cardiac myocytes against ischemia–reperfusion injury, Drug and Chemical Toxicology, 42, 2, 2019. Crossref

  2. Barsain Bharati Lalhal, Yadav Sudesh Kumar, Picrorhiza kurrooa Royle ex Benth., an Endangered Himalayan Elixir- Medicinal Importance and Exploration of Biotechnological Approaches in Picroside Production, Current Traditional Medicine, 5, 4, 2019. Crossref

  3. Akbar Shahid, Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in Handbook of 200 Medicinal Plants, 2020. Crossref

  4. Okwudiri Ihegboro Godwin, James Ononamadu Chimaobi, Drug-Induced Hepatotoxicity, in Hepatotoxicity [Working Title], 2022. Crossref

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