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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radioprotective Effects of Aloe Vera Leaf Extract on Swiss Albino Mice against Whole-Body Gamma Irradiation

Volume 28, Issue 1, 2009, pp. 53-61
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i1.60
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ABSTRACT

The skin, being a cell-renewal system, is one of the first organs to be affected in total-body irradiation during radiotherapy. An attempt has been made in the present study to explore radiation-induced biochemical alterations caused by whole-body gamma irradiation and their modulation in Swiss albino mice by Aloe vera leaf extract (AVE). Mice were selected for this study from an inbreed colony and divided into four different groups: I (double-distilled water-treated group): considered as normal; II (Aloe vera-treated group): the animals were administered 1 g/kg body-wt/day Aloe vera leaf extract; III (radiation-treated group): the animals were exposed to 6 Gy gamma radiation at the dose rate of 0.96 Gy/min; and IV (combination group): animals were administered Aloe vera leaf extract continuously for 15 consecutive days, and on the 15th day they were irradiated to 6 Gy gamma radiation after 30 minutes of extract administration. The animals from the above groups were autopsied after 6 hours, 24 hours, and at 3, 7, 14, and 21 days of radiation. Biochemical estimations of DNA, lipid peroxidation, glutathione, catalase, and superoxide-dismutase were made. Total DNA, catalase, superoxide dismutase (SOD) activity in the skin, and glutathione (GSH) in the liver and blood significantly decreased compared to normal, but lipid peroxidation (LPO) in the liver and blood increased in the irradiated control group. In contrast, in experimental animals, DNA, catalase, and SOD in the skin and GSH in the liver and blood increased significantly, whereas LPO in the liver and blood decreased in comparison to irradiated control animals. Thus, Aloe vera leaf extract is found to have damage-resistant properties against radiation-induced biochemical alterations in Swiss albino mice.

CITED BY
  1. Saini Dinesh Kumar, Saini Mali Ram, Evaluation of radioprotective efficacy and possible mechanism of action of Aloe gel, Environmental Toxicology and Pharmacology, 31, 3, 2011. Crossref

  2. Siew Yin-Yin, Zareisedehizadeh Sogand, Seetoh Wei-Guang, Neo Soek-Ying, Tan Chay-Hoon, Koh Hwee-Ling, Ethnobotanical survey of usage of fresh medicinal plants in Singapore, Journal of Ethnopharmacology, 155, 3, 2014. Crossref

  3. P.R Archana, Rao B. Nageshwar, Rao B.S. Satish, In vivo radioprotective potential of thymol, a monoterpene phenol derivative of cymene, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 726, 2, 2011. Crossref

  4. Salem Ahmed M., Mohammaden Tarek F., Ali Mohamed A.M., Mohamed Enas A., Hasan Hesham F., Ellagic and ferulic acids alleviate gamma radiation and aluminium chloride-induced oxidative damage, Life Sciences, 160, 2016. Crossref

  5. Jagetia Ganesh Chandra, Shetty Prakash Chandra, Vidyasagar Mamidipudi Srinivasa, Inhibition of Radiation-Induced DNA Damage by Jamun, Syzygium cumini, in the Cultured Splenocytes of Mice Exposed to Different Doses of γ-Radiation, Integrative Cancer Therapies, 11, 2, 2012. Crossref

  6. Rao Suresh, Hegde Sanath, Baliga-Rao Manjeshwar, Palatty Princy, George Thomas, Baliga Manjeshwar, An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study, Medicines, 4, 3, 2017. Crossref

  7. Mishra Krishnanand, Alsbeih Ghazi, Appraisal of biochemical classes of radioprotectors: evidence, current status and guidelines for future development, 3 Biotech, 7, 5, 2017. Crossref

  8. Yarnell Eric, Abascal Kathy, Botanical Medicines and Ionizing Radiation: Part 1—Radioprotective Herbs, Alternative and Complementary Therapies, 17, 6, 2011. Crossref

  9. Haniadka Raghavendra, Kamble Pratibha S., Azmidha Ayesha, Mane Prajwal Prabhudev, Geevarughese Nikku Mathew, Palatty Princy Louis, Baliga Manjeshwar Shrinath, Review on the Use of Aloe vera (Aloe) in Dermatology, in Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013. Crossref

  10. AL-Harbi Mohammad S., Antioxidant, Protective Effect of Black Berry and Quercetin Against Hepatotoxicity Induced by Aluminum Chloride in Male Rats, International Journal of Pharmacology, 15, 4, 2019. Crossref

  11. Akbar Shahid, Aloe vera (L.) Burm.f. (Asphodelaceae/Xanthorrhoeaceae), in Handbook of 200 Medicinal Plants, 2020. Crossref

  12. Kulawik-Pióro Agnieszka, Goździcka Weronika Joanna, Plant and Herbal Extracts as Ingredients of Topical Agents in the Prevention and Treatment Radiodermatitis: A Systematic Literature Review, Cosmetics, 9, 3, 2022. Crossref

  13. Kalekhan Faizan, Kudva Avinash K., Raghu Shamprasad V., Rao Suresh, Hegde Sanath K., Simon Paul, Baliga Manjeshwar S., Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced, Anti-Cancer Agents in Medicinal Chemistry, 22, 1, 2022. Crossref

  14. Shivappa Pooja, Bernhardt GrisildaVidya, Natural radioprotectors on current and future perspectives: A mini-review, Journal of Pharmacy And Bioallied Sciences, 14, 2, 2022. Crossref

  15. Wang Tingting, Liao Jian, Zheng Liying, Zhou Yi, Jin Qianru, Wu Yanjing, Aloe vera for prevention of radiation-induced dermatitis: A systematic review and cumulative analysis of randomized controlled trials, Frontiers in Pharmacology, 13, 2022. Crossref

  16. Raj Seema, Manchanda Romila, Bhandari Meena, Alam Md. Sabir, Review on Natural Bioactive Products as Radioprotective Therapeutics: Present and Past Perspective, Current Pharmaceutical Biotechnology, 23, 14, 2022. Crossref

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