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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Expression of NF-κB and ERK Following Heavy Ion Irradiation

Volume 23, Issue 1, 2004, 8 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i1.50
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ABSTRACT

Heavy ion irradiation of cells is known to increase cytotoxic, mutagenic, and carcinogenic effects. The increased biological effectiveness of these ions is as yet unexplained, except for the fact that, unlike γ-radiation, they result in clustered damage. It is likely that the increased biological effectiveness is a consequence of altered signaling pattern, which in turn may be due to the difference in the nature of damage produced. Gamma irradiation has been known to activate both pro- and anti-apoptotic signaling pathways. Nuclear factor-κB (NF-κB) and extracellular signal regulated kinase (ERK) contribute to the survival of the irradiated cell. Moreover, NF-κB acts as a redox sensor. In the present study, we examined NF-κB and ERK as antiapoptotic factors that could lead to the inhibition of apoptosis and, consequently, to increased mutagenicity. Both these signaling factors show a fluctuation in their levels with time.

CITED BY
  1. Narang Himanshi, Bhat Nagesh, Gupta S. K., Santra S., Choudhary R. K., Kailash S., Krishna Malini, Differential activation of mitogen-activated protein kinases following high and low LET radiation in murine macrophage cell line, Molecular and Cellular Biochemistry, 324, 1-2, 2009. Crossref

  2. Hellweg Christine E., Baumstark-Khan Christa, Schmitz Claudia, Lau Patrick, Meier Matthias M., Testard Isabelle, Berger Thomas, Reitz Günther, Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer, International Journal of Radiation Biology, 87, 9, 2011. Crossref

  3. Hellweg Christine E, Baumstark-Khan Christa, Schmitz Claudia, Lau Patrick, Meier Matthias M, Testard Isabelle, Berger Thomas, Reitz Günther, Carbon-Ion-Induced Activation of the NF-κB Pathway, Radiation Research, 175, 4, 2011. Crossref

  4. Fujita Mayumi, Imadome Kaori, Shoji Yoshimi, Isozaki Tetsurou, Endo Satoshi, Yamada Shigeru, Imai Takashi, Carbon-Ion Irradiation Suppresses Migration and Invasiveness of Human Pancreatic Carcinoma Cells MIAPaCa-2 via Rac1 and RhoA Degradation, International Journal of Radiation Oncology*Biology*Physics, 93, 1, 2015. Crossref

  5. Hellweg Christine E., The Nuclear Factor κB pathway: A link to the immune system in the radiation response, Cancer Letters, 368, 2, 2015. Crossref

  6. Zhang Ye, Moreno-Villanueva Maria, Krieger Stephanie, Ramesh Govindarajan, Neelam Srujana, Wu Honglu, Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences, International Journal of Molecular Sciences, 18, 6, 2017. Crossref

  7. Han Ying-Hao, Kwon Jeong-Hoon, Yu Dae-Yeul, Moon Eun-Yi, Inhibitory effect of peroxiredoxin II (Prx II) on Ras–ERK–NFκB pathway in mouse embryonic fibroblast (MEF) senescence, Free Radical Research, 40, 11, 2006. Crossref

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