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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Protective Effect of Solanum muricatum on Tumor Metastasis by Regulating Inflammatory Mediators and Nuclear Factor-Kappa B Subunits

Volume 34, Issue 3, 2015, pp. 249-262
DOI: 10.1615/JEnvironPatholToxicolOncol.2015010308
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ABSTRACT

Metastasis is one of the hallmarks of malignant neoplasm or cancer, which is the leading cause of death in many cancer patients. A major challenge in cancer treatment is to find better ways to specifically target tumor metastases. In this study, the anti-metastatic potential of the methanol extract of Solanum muricatum (S. muricatum) was evaluated using B16F-10 melanoma cell−induced lung metastasis in C57BL/6 mice. Treatment with S. muricatum significantly inhibited the lung tumor nodule formation and reduced the lung collagen hydroxyproline, hexosamine, and uronic acid levels (p<0.01). Similarly, serum sialic acid and γ-glutamyl transpeptidase levels were also significantly inhibited after S. muricatum treatment. The levels of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, granulocyte monocyte colony-stimulating factor (GM-CSF), and IL-2 in serum were significantly regulated after treatment with S. muricatum. The serum nitric oxide level was also decreased significantly and was accompanied by a decrease in inducible nitric oxide synthase (iNOS) and cyclo- oxygenase (COX)-2 expressions after S. muricatum treatment. The present study reveals that S. muricatum treatment was able to alter the proinflammatory cytokine production as well as inhibit the activation and nuclear translocation of nuclear factor-κB (p65 and p50) subunits.

CITED BY
  1. Zhao Rui, Zhang Tao, Ma Baoling, Li Xing, Antitumor Activity ofPortulaca OleraceaL. Polysaccharide on HeLa Cells Through Inducing TLR4/NF-κB Signaling, Nutrition and Cancer, 69, 1, 2017. Crossref

  2. Wang Nan, Wang Feng, Gao Youshui, Zhou Zubin, Liu Wei, Pan Chenhao, Yin Peipei, Tang Mingjie, Yu Xiaowei, Solanum Muricatum Promotes Osteogenic Differentiation of Rat Bone Marrow Stromal Cells, Journal of Food Science, 82, 7, 2017. Crossref

  3. Yarlagadda Keerthi, Hassani John, Foote Isaac P., Markowitz Joseph, The role of nitric oxide in melanoma, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1868, 2, 2017. Crossref

  4. Chugh N.A., Koul A., Altered presence of extra cellular matrix components in murine skin cancer: Modulation by Azadirachta indica leaf extract, Journal of Traditional and Complementary Medicine, 11, 3, 2021. Crossref

  5. Yang Shipeng, Zhu Haodong, Huang Liping, Zhang Guangnan, Wang Lihui, Jiang Xiaoting, Zhong Qiwen, Transcriptome-wide and expression analysis of the NAC gene family in pepino (Solanum muricatum) during drought stress, PeerJ, 9, 2021. Crossref

  6. Rios Raimon, Silva Hugo Bernardino Ferreira da, Carneiro Norma Vilany Queiroz, Pires Anaque de Oliveira, Carneiro Tamires Cana Brasil, Costa Ryan dos Santos, Marques Cintia Rodrigues, Machado Marta Santos Serafim, Velozo Eudes da Silva, Silva Telma M.G. da, Silva Tania M.S. da, Conceição Adilva de Souza, Alcântara-Neves Neuza Maria, Figueiredo Camila Alexandrina, Solanum paniculatum L. decreases levels of inflammatory cytokines by reducing NFKB, TBET and GATA3 gene expression in vitro, Journal of Ethnopharmacology, 209, 2017. Crossref

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