Library Subscription: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Scientific Documentation of the Relationship of Vitamin D Deficiency and the Development of Cancer

Volume 28, Issue 2, 2009, pp. 133-141
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i2.50
Get accessGet access

ABSTRACT

It is well known that vitamin D plays a key role in calcium homeostasis and is important for optimal skeletal growth. The major function of vitamin D is to enhance the efficiency of calcium absorption from the small intestine. Most physicians relate vitamin D deficiency to disorders of skeletal muscle. Vitamin D deficiency in children can manifest itself as rickets. In adults, vitamin D deficiency results in osteomalacia. Because most physicians do not appreciate the role of vitamin D deficiency in predisposing the development of cancer, we have written this important report as a wake-up call to physicians and other healthcare workers in documenting the relationship of vitamin D deficiency and cancer. Epidemiological data show an inverse relationship between vitamin D levels and breast cancer incidence. In addition, there is a well-documented association between vitamin D intake and the risk of breast cancer. Low vitamin D intake has also been indicated in colorectal carcinogenesis. A vitamin D deficiency has also been documented in patients with prostate cancer, ovarian cancer, as well as multiple myeloma. Larger randomized clinical trials should be undertaken in humans to establish the role of vitamin D supplementation in the prevention of these cancers.

CITED BY
  1. Verma Mukesh, Patel Payal, Verma Mudit, Biomarkers in Prostate Cancer Epidemiology, Cancers, 3, 4, 2011. Crossref

  2. Plum Lori A., DeLuca Hector F., Vitamin D, disease and therapeutic opportunities, Nature Reviews Drug Discovery, 9, 12, 2010. Crossref

  3. Khan R., Khan B.S. Razib, Diet, disease and pigment variation in humans, Medical Hypotheses, 75, 4, 2010. Crossref

  4. Caron-Jobin Maude, Morisset Anne-Sophie, Tremblay Angelo, Huot Céline, Légaré Denis, Tchernof André, Elevated Serum 25(OH)D Concentrations, Vitamin D, and Calcium Intakes Are Associated With Reduced Adipocyte Size in Women, Obesity, 19, 7, 2011. Crossref

  5. De Jaeger C., Cherin P., Vitamine D : effets sur la santé . Recommandations de bon usage, Médecine & Longévité, 2, 4, 2010. Crossref

  6. Toman Emma, Bishop Jonathon R.B., Davies David J., Su Zhangjie, Criseno Sherwin, Mason Andrea, Toogood Andrew A., Belli Antonio, Vitamin D Deficiency in Traumatic Brain Injury and Its Relationship with Severity of Injury and Quality of Life: A Prospective, Observational Study, Journal of Neurotrauma, 34, 7, 2017. Crossref

  7. Gedik Habip, Vitamin D Deficiency and its Effects on Patients with Multiple Myeloma, Hematology & Transfusion International Journal, 5, 2, 2017. Crossref

  8. Marchand Lucille R., Breast Cancer, in Integrative Medicine, 2012. Crossref

  9. Rizvi Asim, Naseem Imrana, Causing DNA damage and stopping DNA repair – Vitamin D supplementation with Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors may cause selective cell death of cancer cells: A novel therapeutic paradigm utilizing elevated copper levels within the tumour, Medical Hypotheses, 144, 2020. Crossref

  10. Lei Wei-Te, Huang Kai-Yao, Jhong Jhih-Hua, Chen Chia-Hung, Weng Shun-Long, Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants, Scientific Reports, 11, 1, 2021. Crossref

  11. Bajbouj Khuloud, Sahnoon Lina, Shafarin Jasmin, Al-Ali Abeer, Muhammad Jibran Sualeh, Karim Asima, Guraya Salman Y., Hamad Mawieh, Vitamin D-Mediated Anti-cancer Activity Involves Iron Homeostatic Balance Disruption and Oxidative Stress Induction in Breast Cancer, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  12. Maurya Shweta, Tripathi Anil Kumar, Verma Shailendra Prasad, Preinduction Serum Vitamin D3 Levels and Induction Chemotherapy Remission Rates in Patients with Acute Leukemia, Nutrition and Cancer, 74, 10, 2022. Crossref

  13. Uchiyama Ryutaro, Spicer Rachel, Muthukrishna Michael, Cultural evolution of genetic heritability, Behavioral and Brain Sciences, 45, 2022. Crossref

  14. Sherif Zaki A., Vitamin D: A Potential Prophylactic and Therapeutic Agent against COVID-19, in Frontiers of COVID-19, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain