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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Cancer Stem Cells in the Mechanism of Metal Carcinogenesis

Volume 31, Issue 3, 2012, pp. 245-263
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i3.60
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ABSTRACT

Environmental metal carcinogenesis is a major public health concern. The mechanism underlying metal-induced carcinogenesis remains unclear. The concept of cancer stem cell recently has drawn considerable attention. Various studies indicate that the generation of cancer stem cells might contribute to the overall mechanism of development of metal-induced cancer. It is believed that oxidative stress and abnormal signaling caused by metals lead to the enrichment of cancer stem cells and eventually initiate cancer. In addition, metal-induced angiogenesis may also contribute to the generation of cancer stem cells. Studies using animal models further suggest that metals could induce the production of cancer stem cells and thus cause the development of cancer. This review summarizes recent studies of oxidative stress and cancer stem cells in relation to the mechanism of metal carcinogenesis.

CITED BY
  1. Stannard Leanne, Doak Shareen H., Doherty Ann, Jenkins Gareth J., Is Nickel Chloride really a Non-Genotoxic Carcinogen?, Basic & Clinical Pharmacology & Toxicology, 121, 2017. Crossref

  2. Salim Elsayed I, Hegazi Mona M, Kang Jin Seok, Helmy Hager M, Expression Patterns of Cancer Stem Cell Markers During Specific Celecoxib Therapy in Multistep Rat Colon Carcinogenesis Bioassays, Asian Pacific Journal of Cancer Prevention, 17, 3, 2016. Crossref

  3. Wang Lei, Fan Jia, Hitron John Andrew, Son Young-Ok, Wise James T.F., Roy Ram Vinod, Kim Donghern, Dai Jin, Pratheeshkumar Poyil, Zhang Zhuo, Shi Xianglin, Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation, Toxicological Sciences, 151, 2, 2016. Crossref

  4. Wise James T.F., Wang Lei, Zhang Zhuo, Shi Xianglin, The 9th Conference on Metal Toxicity and Carcinogenesis: The conference overview, Toxicology and Applied Pharmacology, 331, 2017. Crossref

  5. Wang Zhishan, Yang Chengfeng, Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis, Seminars in Cancer Biology, 57, 2019. Crossref

  6. Jiao Yang, Wang Yirong, Guo Shanchun, Wang Guangdi, Glutathione peroxidases as oncotargets, Oncotarget, 8, 45, 2017. Crossref

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