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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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In Vitro Evidence of the Role of COX-2 in Attenuating Gastric Inflammation and Promoting Gastric Carcinogenesis

Volume 21, Issue 2, 2002, 12 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i2.100
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ABSTRACT

Although gastric adenocarcinoma is one of the most common malignancies in the world, little is known about its exact molecular processes in development and progression. Recent studies suggest that COX-2 is important in carcinogenesis of gastrointestinal cancers, and is especially involved in carcinogenesis in a mouse model of familial adenomatosis polyposis. To understand the role of COX-2 in gastric carcinogenesis and Helicobacter pylori-associated gastritis, we measured COX-2 expression in 170 human gastric carcinoma tissues by immunohistochemical analysis and compared the expression of COX-2 in paired tissues obtained from normal-looking and cancer-bearing mucosa. Further evidence of the involvement of COX-2 in gastritis and gastric carcinogenesis was obtained by establishing stable cell lines overexpressing COX-2. After subcloning of COX-2 into pCB7 mammalian expression vector, two stable cell lines named MKN-28-COX-2 and MKN-45-COX-2 were generated by transfection of COX-2 cDNA. To understand the effect of COX-2 on gastritis, we performed an electrophoretic mobility shift assay of NF-kB (inflammation-associated transcription factor), and measured malondialdehyde levels and chemiluminescence activities in both mock-transfected MKN and MKN-COX-2 cells after stimulation of H. pylori (1 x 106 CFU/mL) and neutrophils (102 cells/mL). A marked attenuation ofNF-kB bindings and generation of free radicals was observed in COX-2 overexpressed cells. Another set of experiments, including the growth inhibition by TGF-b treatment, Matrigel invasion assay, and apoptosis assay, was done. COX-2 showed the advantage of the escape from the growth inhibition by TGF-b through decreasing TGF-b RII expression and increased cell invasiveness. In conclusion, COX-2 expression seems to be induced to attenuate the degree of atrophic gastritis, the initial event in gastric carcinogenesis, and promote gastric carcinogenesis.

CITED BY
  1. Erovic B. M., Woegerbauer M., Pammer J., Selzer E., Grasl M. Ch., Thurnher D., Strong evidence for up-regulation of cyclooxygenase-1 in head and neck cancer, European Journal of Clinical Investigation, 38, 1, 2007. Crossref

  2. Liu Z., Wang X., Lu Y., Han S., Zhang F., Zhai H., Lei T., Liang J., Wang J., Wu K., Fan D., Expression of 15-PGDH is downregulated by COX-2 in gastric cancer, Carcinogenesis, 29, 6, 2008. Crossref

  3. Clausen Ina, Kietz Silke, Fischer Bernd, Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst, Reproductive Toxicology, 20, 1, 2005. Crossref

  4. Zhang Yang, Pan Kai-feng, Zhang Lian, Ma Jun-ling, Zhou Tong, Li Ji-you, Shen Lin, You Wei-cheng, Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China, Carcinogenesis, 2015. Crossref

  5. Li Nianshuang, Xie Chuan, Lu Nong-Hua, Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis, Frontiers in Cellular and Infection Microbiology, 5, 2015. Crossref

  6. Badrey Mohamed, Abdel-Aziz Hassan, Gomha Sobhi, Abdalla Mohamed, Mayhoub Abdelrahman, Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors, Molecules, 20, 8, 2015. Crossref

  7. Fu Suo-Lin, Anti-cancer effects of COX-2 inhibitors and their correlation with angiogenesis and invasion in gastric cancer, World Journal of Gastroenterology, 10, 13, 2004. Crossref

  8. Fosslien Egil, The Hormetic Morphogen Theory of Curvature and the Morphogenesis and Pathology of Tubular and other Curved Structures, Dose-Response, 7, 4, 2009. Crossref

  9. Park Soojin, Kim Won Seok, Choi Un Jung, Han Sang Uk, Kim Yong Seok, Kim Young Bae, Chung Myung Hee, Nam Ki-Tak, Kim Dae Yong, Cho Sung Won, Hahm Ki-Baik, Amelioration of Oxidative Stress with Ensuing Inflammation Contributes to Chemoprevention ofH. pylori-Associated Gastric Carcinogenesis, Antioxidants & Redox Signaling, 6, 3, 2004. Crossref

  10. Robinson Karen, Atherton John C., Helicobacter pylori, in Sequelae and Long-Term Consequences of Infectious Diseases, 2014. Crossref

  11. Berbecka Monika, Forma Alicja, Baj Jacek, Furtak-Niczyporuk Marzena, Maciejewski Ryszard, Sitarz Robert, A Systematic Review of the Cyclooxygenase-2 (COX-2) Expression in Rectal Cancer Patients Treated with Preoperative Radiotherapy or Radiochemotherapy, Journal of Clinical Medicine, 10, 19, 2021. Crossref

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