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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.625 5-Year IF: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018027078
pages 291-303

Antiarthritic Activity of Diallyl Disulfide against Freund’s Adjuvant–Induced Arthritic Rat Model

Yuqing Chen
Department of Orthopedics Surgery, Xinghua Affiliated Hospital of Yangzhou University, Jiangsu Province, 225700, China
Rong Xue
Department of Orthopedics Surgery, Xinghua Affiliated Hospital of Yangzhou University, Jiangsu Province, 225700, China
Xiaochen Jin
Department of Orthopedics Surgery, Xinghua Affiliated Hospital of Yangzhou University, Jiangsu Province, 225700, China
Xiangqi Tan
Department of Orthopedics Surgery, Xinghua Affiliated Hospital of Yangzhou University, Jiangsu Province, 225700, China

ABSTRACT

Diallyl disulfide (DADS) is an organosulfur compound derived mainly from garlic and genus Allium plants, which possess diverse biological properties. The aim of the present study was to evaluate the antiarthritic activity of DADS in rats with arthritis induced using complete Freund's adjuvant (CFA). DADS (20 mg/kg and 50 mg/kg) was administered and tested against CFA-induced arthritic rats by assessing various parameters: body weight, paw volume, arthritic score, organ indices (spleen and thymus), hematological and biochemical parameters, and proinflammatory cytokines. Histopathological analyses were also performed. The treatment of rats with DADS provoked significant reductions in paw volume, edema formation, arthritic score, and organ indices, together with significant improvement in body weight. DADS treatment also improved joint destruction and reduced inflammation, which was supported by histopathological studies. DADS significantly reduced the white blood cell count and improved red blood cell count in CFA-induced rats. The anti-arthritic activity in the CFA-induced rats was further confirmed by biochemical analysis. These findings suggest that DADS prevented cartilage destruction, improved health status, and reduced inflammation by decreasing the expression of proinflammatory cytokines in arthritis-induced rats. Hence, DADS may be a potential therapeutic candidate for the treatment of rheumatoid arthritis.


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