Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.625 5-Year IF: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i4.20
pages 255-261

Acute Exposure of Uranyl Nitrate Causes Lipid Peroxidation and Histopathological Damage in Brain and Bone of Wistar Rat

Somnath Ghosh
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400 085, India
Amit Kumar
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
Badri Narain Pandey
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Kaushala Prasad Mishra
Department of Life Sciences, University of Mumbai, Mumbai, India; Nehru Gram Bharati University, Allahabad, UP, India; Foundation for Education and Research, India and BM International Research Centre, Mumbai, India

ABSTRACT

Although the kidneys are the main target organs for uranium (U) toxicity, recent studies have shown that U can cross the blood-brain barrier to accumulate in the brain. Uranyl nitrate (U-238)—induced oxidative damage was investigated in brain and bone of Wistar rats after intraperitoneal injection of uranyl nitrate at acute doses either nephrotoxic (576 μg of U/kg body weight) or subnephrotoxic (144 μg U/kg body weight). The health effects of U administration at 576 μg of U/kg body weight were seen in terms of decrease in food intake and no gain in body weight compared to respective controls. These alterations were correlated with increased lipid peroxidation as measured by thiobarbituric acid reactive substances in rat brain and bone. However, at lower dosage of U (144 μg U/kg body weight), no significant lipid peroxidation was observed in brain and bone. Histological examination of U-treated (576 μg of U/kg body weight) rat brain tissues showed marked and diffuse cystic degeneration and a similar pattern in histological alterations was observed in kidneys in treated animals; whereas no significant histological change was observed in rat brains and kidney treated with a lower dose of U (144 μg U/kg body weight). It is concluded that administration of U at an acute nephrotoxic dose caused oxidative stress in brain and bone manifested as lipid peroxidation and histopathological damage.


Articles with similar content:

Toxic Effects of Lead Exposure in Rats: Involvement of Oxidative Stress, Genotoxic Effect, and the Beneficial Role of N-Acetylcysteine Supplemented with Selenium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Samta Sharma, Bhanu Pratap Singh Raghuvanshi, Sangeeta Shukla
Protective Role of Naringenin Against Doxorubicin-Induced Cardiotoxicity in a Rat Model: Histopathology and mRNA Expression Profile Studies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Kumaresan Ganesan, Murugesan Ramachandran, Swathika Subburaman
Reversal of Lead-Induced Acute Toxicity by Lipoic Acid with Nutritional Supplements in Male Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Sadhana Shrivastava, Yamini Sharma, Sangeeta Shukla
Protective Effects of Extract from Sclerotium of the King Tuber Medicinal Mushroom, Pleurotus tuberregium (Higher Basidiomycetes) on Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Albino Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 12
Christopher C. Osubor, Chidube A. Alagbaoso, Omoanghe S. Isikhuemhen
Protective Effect of Curcumin Against Carbofuran-Induced Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 1
Binitha P. Purushothaman, Ramadasan Kuttan