Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.625 5-Year IF: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2015010089
pages 1-10

Association Between Biomarkers of Oxidative Stress, Trace Elements, and Cell Proliferation Index in Patients With Benign and Malignant Breast Diseases

Kanchan Karki
Scientific Officer, Molecular Diagnostic and Nanotechnology Laboratory, Uttarakhand Council for Biotechnology, Haldi, U.S. Nagar, 263146, India
Deepti Pande
Department of Biophysics, Banaras Hindu University, Varanasi, India
Reena Negi
Department of Biophysics, Banaras Hindu University, Varanasi, India
Seema Khanna
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Ranjana S. Khanna
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India
Hari D. Khanna
Exprofessor and Head, Department of Biophysics, Banaras Hindu University, Varanasi-221005, India

ABSTRACT

To understand the association between biomarkers of oxidative stress, antioxidants, trace elements, and cell proliferation index in relation to the disease progression in the pathophysiology of breast diseases. Design and Methods: Concentrations of markers of oxidative stress, antioxidants, trace elements, and cell proliferation index were evaluated in the patients with benign breast diseases, malignant breast diseases, and healthy volunteers as controls. Multinomial logistic regression analysis was used to identify the contribution of the selected indexes using odds ratio and associated confidence interval. Results: The level of markers of oxidative stress (malondialdehyde [MDA]) and cell proliferation index were found to be significantly higher with significantly depleted levels of antioxidants and trace elements in breast cancer patients compared with control subjects as well as benign breast disease patients. A similar pattern of changes were observed between benign and control subjects. Conclusion: An inadequate amount of antioxidant enzymes and trace elements may be an important contributing factor associated with oxidative stress leading to elevated levels of MDA and cell proliferation index in relation to disease progression and clinical stage in the pathophysiology of breast diseases.


Articles with similar content:

Biochemical Investigation of Tissue Oxidative Stress and Angiogenesis with Associated Trace Elements in Breast Disease Patients in Uttarakhand, India
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 4
Priyanka Chandra, Hari D. Khanna, K. S. Shahi, Rashmi Bisht, Kanchan Karki, Jeetendra Singh Bohra
Common Variants rs3815188 and rs1043994 on Notch3 Gene Confer Susceptibility to Lung Cancer: A Hospital-Based Case–Control Study
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 1
Faruk Saydam, Guntulu Ak, Cansu Ozbayer, Irfan Degirmenci, Muzaffer Metintas, Emine Yagci
The Prognostic Value of Breast Cancer Resistance Protein (BCRB/ABCG2) Expression in Breast Carcinomas
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Ola M. Omran
Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 1
Tasnim Farasat, Saima Sharif, Farkhanda Manzoor, Shahjahan, Shagufta Naz, Maha Maqsood
Matrix Metalloproteinase-9 as a Potential Tumor Marker in Breast Cancer
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Hrishikesh Sil, Syamsundar Mandal, Amitava Chatterjee, Durga Prasad Nanda, Jaydip Biswas, Shuvojit Moulik