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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Effect of Chokeberry Juice on N-Nitrosodiethylamine-Induced Rat Liver Carcinogenesis

Volume 35, Issue 4, 2016, pp. 317-331
DOI: 10.1615/JEnvironPatholToxicolOncol.2016014030
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ABSTRACT

Because humans commonly consume chokeberry, especially as a nutritional supplement, it must be checked to determine whether its excessive ingestion can cause adverse effects, in particular, in the case of simultaneous exposure to some xenobiotics. From this point of view, we examined the impact of long-term cotreatment of rats with chokeberry juice and hepatic carcinogen N-nitrosodiethylamine (NDEA) on oxidative damages and neoplastic lesions in the liver of rats. Daily exposure to chokeberry juice in a concentration of 10 g/kg feed via diet for 13 wk led to an intensified hepatotoxic effect of NDEA (0.01% in drinking water for 13 wk), as evidenced by changes in histopathological architecture of liver tissue, increased lipid peroxidation, protein carbonyl formation, and DNA degradation. Moreover, we noticed an increase in relative liver weight and a decrease in body weight in this group in comparison to NDEA-alone treated animals. Chokeberry juice applied alone did not cause any adverse effects in rats. On the basis of these findings, it can be concluded that high doses and longterm administration of chokeberry juice may enhance tumor-promoting action of some chemical carcinogens.

CITED BY
  1. Sidor Andrzej, Drożdżyńska Agnieszka, Gramza-Michałowska Anna, Black chokeberry (Aronia melanocarpa) and its products as potential health-promoting factors - An overview, Trends in Food Science & Technology, 89, 2019. Crossref

  2. Kalemba-Drożdż Małgorzata, Cierniak Agnieszka, Cichoń Iwona, Wang Li-Shu, Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP, Journal of Berry Research, 10, 1, 2020. Crossref

  3. Rodrigues Keuri Eleutério, de Oliveira Fábio Rodrigues, Barbosa Benilson Ramos Cassunde, Paraense Ricardo S. Oliveira, Bannwart Cahy Manoel, Pinheiro Bruno Gonçalves, Botelho Anderson de Santana, Muto Nilton Akio, do Amarante Cristine Bastos, Hamoy Moises, Macchi Barbarella de Matos, Maia Cristiane do Socorro Ferraz, do Prado Alejandro Ferraz, do Nascimento José Luiz Martins, Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to methylmercury, Food and Chemical Toxicology, 133, 2019. Crossref

  4. Witucki Łukasz, Kurpik Monika, Jakubowski Hieronim, Szulc Michał, Łukasz Mikołajczak Przemysław, Jodynis-Liebert Jadwiga, Kujawska Małgorzata, Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease, Nutrients, 14, 10, 2022. Crossref

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