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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Long-Term Effects of Chromatin Remodeling and DNA Damage in Stem Cells Induced by Environmental and Dietary Agents

Volume 32, Issue 4, 2013, pp. 307-327
DOI: 10.1615/JEnvironPatholToxicolOncol.2013007980
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ABSTRACT

The presence of histones acts as a barrier to protein access; thus chromatin remodeling must occur for essential processes such as transcription and replication. In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Chromatin remodeling is also interconnected with the DNA damage response, maintenance of stem cell properties, and cell differentiation programs. Chromatin modifications have increasingly been shown to produce long-lasting alterations in chromatin structure and transcription. Recent studies have shown environmental exposures in utero have the potential to alter normal developmental signaling networks, physiologic responses, and disease susceptibility later in life during a process known as developmental reprogramming. In this review we discuss the long-term impact of exposure to environmental compounds, the chromatin modifications that they induce, and the differentiation and developmental programs of multiple stem and progenitor cell types altered by exposure. The main focus is to highlight agents present in the human lifestyle that have the potential to promote epigenetic changes that impact developmental programs of specific cell types, may promote tumorigenesis through altering epigenetic marks, and may be transgenerational, for example, those able to be transmitted through multiple cell divisions.

CITED BY
  1. Bariar Bhawana, Vestal C. Greer, Deem Bradley, Goodenow Donna, Ughetta Mimi, Engledove R. Warren, Sahyouni Mark, Richardson Christine, Bioflavonoids promote stable translocations betweenMLL-AF9breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks, Environmental and Molecular Mutagenesis, 60, 2, 2019. Crossref

  2. García-Fortea Pedro, Cohen-Corcia Isaac, Córdoba-Doña Juan Antonio, Reche-Rosado Alberto, González-Mesa Ernesto, Toxic elements in hair and in vitro fertilization outcomes: A prospective cohort study, Reproductive Toxicology, 77, 2018. Crossref

  3. Hu Junjie, Yu Yingxin, Epigenetic response profiles into environmental epigenotoxicant screening and health risk assessment: A critical review, Chemosphere, 226, 2019. Crossref

  4. Migliorini Filippo, Tingart Markus, Maffulli Nicola, Progress with stem cell therapies for tendon tissue regeneration, Expert Opinion on Biological Therapy, 20, 11, 2020. Crossref

  5. Goodenow Donna, Emmanuel Faith, Berman Chase, Sahyouni Mark, Richardson Christine, Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 849, 2020. Crossref

  6. Goodenow Donna, Lalwani Kiran, Richardson Christine, DNA Damage and Repair Mechanisms Triggered by Exposure to Bioflavonoids and Natural Compounds, in DNA - Damages and Repair Mechanisms, 2021. Crossref

  7. Lalwani Kiran, French Caroline, Richardson Christine, Mouse Models to Understand Mutagenic Outcomes and Illegitimate Repair of DNA Damage, in Mutagenesis and Mitochondrial-Associated Pathologies, 2022. Crossref

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