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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis

Volume 35, Issue 3, 2016, pp. 193-205
DOI: 10.1615/JEnvironPatholToxicolOncol.2016014024
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ABSTRACT

Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia. All are reviewed here, including potential biomarkers for malignant transformation of OSF. These interactions are not fully understood, but a critical mass of knowledge is building up to ultimately allow the understanding of all mechanisms involved.

CITED BY
  1. Chaturvedi Pankaj, Malik Akshat, Nair Deepa, Nair Sudhir, Mishra Aseem, Garg Apurva, Vaishampayan Sagar, Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 124, 3, 2017. Crossref

  2. Arakeri Gururaj, Patil Shekar Gowda, Aljabab Abdulsalam S., Lin Kuan-Chou, Merkx M. A. W., Gao Shan, Brennan Peter A., Oral submucous fibrosis: An update on pathophysiology of malignant transformation, Journal of Oral Pathology & Medicine, 46, 6, 2017. Crossref

  3. Gomes Carolina Cavalieri, Diniz Marina Gonçalves, Gomez Ricardo Santiago, The Molecular Basis of Carcinogenesis, in Premalignant Conditions of the Oral Cavity, 2019. Crossref

  4. Shih Yin-Hwa, Wang Tong-Hong, Shieh Tzong-Ming, Tseng Yu-Hsin, Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy, International Journal of Molecular Sciences, 20, 12, 2019. Crossref

  5. Shen Yen-Wen, Shih Yin-Hwa, Fuh Lih-Jyh, Shieh Tzong-Ming, Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments, International Journal of Molecular Sciences, 21, 19, 2020. Crossref

  6. Patel Falguni, Shah Shreyas N. , James Christina , Oral Submucous Fibrosis - A Review, Journal of Evolution of Medical and Dental Sciences, 10, 32, 2021. Crossref

  7. Nawn Debaleena, Pratiher Sawon, Chattoraj Subhankar, Chakraborty Debjani, Pal Mousumi, Paul Ranjan Rashmi, Dutta Srimonti, Chatterjee Jyotirmoy, Multifractal Alterations in Oral Sub-Epithelial Connective Tissue During Progression of Pre-Cancer and Cancer, IEEE Journal of Biomedical and Health Informatics, 25, 1, 2021. Crossref

  8. Alkofahi Hamzah, Ebrahimi Mehdi, Potentially Malignant Disorders of the Oral Cavity, in Early Detection and Treatment of Head & Neck Cancers, 2021. Crossref

  9. Kuo Tzer‐Min, Nithiyanantham Srinivasan, Lee Chi‐Pin, Hsu Hui‐Ting, Luo Shun‐Yuan, Lin You‐Zhe, Yeh Kun‐Tu, Ko Ying‐Chin, Arecoline N‐oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions, Journal of Cellular Physiology, 234, 8, 2019. Crossref

  10. Yadahalli Roopa, Sarode Gargi S., Sarode Sachin C, Khan Zafar Ali, Vyas Nishant, Kharat Avinash H, Bhandi Shilpa, Awan Kamran Habib, Patil Shankargouda, CC group of chemokines and associated gene expression of transcription factors: Deciphering immuno-pathogenetic aspect of oral submucous fibrosis, Disease-a-Month, 2022. Crossref

  11. Shajahan Amina, Mathew Abel Chundankuzhiyil, Gangadharan Vadavattath Padmanabhan, Chandrasekhar Dilip, Tobacco use and clinical leukoplakia lesions among south Indian tribes, Journal of Basic and Clinical Physiology and Pharmacology, 2021. Crossref

  12. Zhang Pangzhen, Chua Nathaniel Quan En, Dang Simon, Davis Ashleigh, Chong Kah Wee, Prime Stephen S., Cirillo Nicola, Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?, International Journal of Molecular Sciences, 23, 3, 2022. Crossref

  13. J Manju., Ramani Priya, B Rabitha ., ORAL SUBMUCOUS FIBROSIS –A REVIEW, GLOBAL JOURNAL FOR RESEARCH ANALYSIS, 2021. Crossref

  14. Suresh Amal, Anehosur Venkatesh, Hallikeri Kaveri, Role of coronoidectomy and temporalis myotomy in surgical management of oral submucous fibrosis, Oral and Maxillofacial Surgery, 26, 1, 2022. Crossref

  15. Hettiarachchi Pilana Vithanage Kalani Shihanika, Anupama Sahani, Akalanka Isuru, Jayasinghe Ruwan Duminda, Clinical characteristics of patients with oral submucous fibrosis—hospital‐based retrospective study in a Sri Lankan cohort, Oral Surgery, 2022. Crossref

  16. Chen Lihui, Yuan Fulai, Chen Sifang, Li Xiong, Kong Lingyu, Zhang Wei, Potential Role of Host Microbiome in Areca Nut-Associated Carcinogenesis and Addiction, Molecules, 27, 23, 2022. Crossref

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