Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
Indexed in
Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis
ABSTRACT
Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia. All are reviewed here, including potential biomarkers for malignant transformation of OSF. These interactions are not fully understood, but a critical mass of knowledge is building up to ultimately allow the understanding of all mechanisms involved.
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Chaturvedi Pankaj, Malik Akshat, Nair Deepa, Nair Sudhir, Mishra Aseem, Garg Apurva, Vaishampayan Sagar, Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 124, 3, 2017. Crossref
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Arakeri Gururaj, Patil Shekar Gowda, Aljabab Abdulsalam S., Lin Kuan-Chou, Merkx M. A. W., Gao Shan, Brennan Peter A., Oral submucous fibrosis: An update on pathophysiology of malignant transformation, Journal of Oral Pathology & Medicine, 46, 6, 2017. Crossref
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Gomes Carolina Cavalieri, Diniz Marina Gonçalves, Gomez Ricardo Santiago, The Molecular Basis of Carcinogenesis, in Premalignant Conditions of the Oral Cavity, 2019. Crossref
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Shih Yin-Hwa, Wang Tong-Hong, Shieh Tzong-Ming, Tseng Yu-Hsin, Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy, International Journal of Molecular Sciences, 20, 12, 2019. Crossref
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Shen Yen-Wen, Shih Yin-Hwa, Fuh Lih-Jyh, Shieh Tzong-Ming, Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments, International Journal of Molecular Sciences, 21, 19, 2020. Crossref
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Patel Falguni, Shah Shreyas N. , James Christina , Oral Submucous Fibrosis - A Review, Journal of Evolution of Medical and Dental Sciences, 10, 32, 2021. Crossref
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Nawn Debaleena, Pratiher Sawon, Chattoraj Subhankar, Chakraborty Debjani, Pal Mousumi, Paul Ranjan Rashmi, Dutta Srimonti, Chatterjee Jyotirmoy, Multifractal Alterations in Oral Sub-Epithelial Connective Tissue During Progression of Pre-Cancer and Cancer, IEEE Journal of Biomedical and Health Informatics, 25, 1, 2021. Crossref
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Alkofahi Hamzah, Ebrahimi Mehdi, Potentially Malignant Disorders of the Oral Cavity, in Early Detection and Treatment of Head & Neck Cancers, 2021. Crossref
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Kuo Tzer‐Min, Nithiyanantham Srinivasan, Lee Chi‐Pin, Hsu Hui‐Ting, Luo Shun‐Yuan, Lin You‐Zhe, Yeh Kun‐Tu, Ko Ying‐Chin, Arecoline N‐oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions, Journal of Cellular Physiology, 234, 8, 2019. Crossref
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Yadahalli Roopa, Sarode Gargi S., Sarode Sachin C, Khan Zafar Ali, Vyas Nishant, Kharat Avinash H, Bhandi Shilpa, Awan Kamran Habib, Patil Shankargouda, CC group of chemokines and associated gene expression of transcription factors: Deciphering immuno-pathogenetic aspect of oral submucous fibrosis, Disease-a-Month, 2022. Crossref
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Shajahan Amina, Mathew Abel Chundankuzhiyil, Gangadharan Vadavattath Padmanabhan, Chandrasekhar Dilip, Tobacco use and clinical leukoplakia lesions among south Indian tribes, Journal of Basic and Clinical Physiology and Pharmacology, 2021. Crossref
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Zhang Pangzhen, Chua Nathaniel Quan En, Dang Simon, Davis Ashleigh, Chong Kah Wee, Prime Stephen S., Cirillo Nicola, Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?, International Journal of Molecular Sciences, 23, 3, 2022. Crossref
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J Manju., Ramani Priya, B Rabitha ., ORAL SUBMUCOUS FIBROSIS –A REVIEW, GLOBAL JOURNAL FOR RESEARCH ANALYSIS, 2021. Crossref
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Suresh Amal, Anehosur Venkatesh, Hallikeri Kaveri, Role of coronoidectomy and temporalis myotomy in surgical management of oral submucous fibrosis, Oral and Maxillofacial Surgery, 26, 1, 2022. Crossref
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Hettiarachchi Pilana Vithanage Kalani Shihanika, Anupama Sahani, Akalanka Isuru, Jayasinghe Ruwan Duminda, Clinical characteristics of patients with oral submucous fibrosis—hospital‐based retrospective study in a Sri Lankan cohort, Oral Surgery, 2022. Crossref
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Chen Lihui, Yuan Fulai, Chen Sifang, Li Xiong, Kong Lingyu, Zhang Wei, Potential Role of Host Microbiome in Areca Nut-Associated Carcinogenesis and Addiction, Molecules, 27, 23, 2022. Crossref