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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014008723
pages 123-130

Effects of Maternally Exposed Food Coloring Additives on Laryngeal Histology in Rats

Kayhan Basak
Dr.Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey
Duygu Kumbul Doguc
Suleyman Demirel University, Medical School, Medical Biochemistry Department, Isparta, Turkey
Firdevs Aylak
Suleyman Demirel University, Medical School, Medical Biochemistry Department, Isparta, Turkey
Nimet Karadayi
Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Pathology, Istanbul, Turkey
Fatih Gultekin
Suleyman Demirel University, Medical School, Medical Biochemistry Department, Isparta, Turkey

ABSTRACT

Experimental reports showed carcinogenic effects of artificial food colors and additives (AFCAs) on many organs, including the head and neck region. We aimed to investigate the effect of AFCAs on laryngeal histomorphology and immunohistochemical expression in maternally exposed rats. "No observable adverse effect levels" of commonly used AFCAs as a mixture were given to female rats before and during gestation. Histopathological and immunohistochemical findings were evaluated in their offspring. Significant decreasing in goblet cell count and cilia loss were observed with AFCAs in maternally exposed rats (p < 0.05). Immunohistochemically, the Ki67 index was significantly increased and villin expression was significantly reduced in laryngeal epithelium in the study group (p < 0.05), whereas expression of cyclooxygenase type 2, Muc-2, Muc-5AC, p53, and epidermal growth factor receptors did not differ between the groups. This study demonstrated that maternal exposure of AFCAs plays a role in the mucosal defense system and possibly in carcinogenesis.


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