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Journal of Environmental Pathology, Toxicology and Oncology
IF: 1.241 5-Year IF: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Print: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2014010949
pages 145-158

Antitumor and Wound Healing Properties of Rubus niveus Thunb. Root

Blassan Plackal George
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India
Thangaraj Parimelazhagan
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India
Thankarajan Sajeesh
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India
Shanmugam Saravanan
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India

ABSTRACT

The main objective of this study is to highlight the importance of Rubus niveus in the pharmaceutical industry for the development of cost-effective drugs. The study was undertaken to explore the HPLC profile, wound healing, antitumor, and free radical scavenging properties of R. niveus. The root of R. niveus was extracted using organic solvents and subjected to in vitro antioxidant assays. Acetone extract, which showed better in vitro antioxidant properties, was evaluated for in vivo antioxidant, wound healing, and antitumor properties. The polyphenolic acetone extract showed significant in vivo antioxidant, wound healing, and antitumor properties. In the wound healing study, complete epithelialization was noticed during the 13th to 17th days for treated groups. The 250 mg/kg group was found to prolong the life span of mice with Ehrlich ascites carcinoma (70.04%) and reduced the volume of Daltons lymphoma ascites solid tumors (2.07 cm3). The HPLC analysis of acetone extract revealed the presence of Quercetin, a natural flavonoid with the retention time of 20.89 min. The results of the current study suggest the use of R. niveus as a valuable natural antioxidant that has an immense scope as an effective source to cure skin diseases, wounds, and tumors.


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