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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Print: 0731-8898

ISSN Online: 2162-6537

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Antimutagenic Potential of Extracts Isolated from Terminalia Arjuna

Volume 20, Issue 1, 2001, 6 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.20
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ABSTRACT

Terminalia arjuna is an important medicinal plants widely used in the preparation of Ayurvedic formulations used against several ailments. The present investigation was aimed at the fractionation of crude extracts from the bark of T. arjuna in order to isolate and purify the antimutagenic factors present. The antimutagenicity assay was performed to check the modulatory effect of these fractions against NPD, sodium azide, and 2AF, using the Ames Salmonella his+ reversion assay. Most of the phenolic fractions exhibited mutagen specificity against directacting mutagens, being effective in suppressing the frameshift mutagen NPD but failing to inhibit sodium azide (base pair substitution)-induced his+ revertants.ET-1 fraction triterpenoid diglycoside showed a marked effect against sodium azide but was ineffective against NPD. In the case of the indirect-acting mutagen 2AF, all the fractions were found to be quite potent in modulating its mutagenicity in both TA98 and TA100 tester strains of Salmonella typhimurium. The results indicate that the bark of T. arjuna harbors constituents with promising antimutagenic/anticarcinogenic potential that should be investigated further.

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  1. Gopinath K., Venkatesh K.S., Ilangovan R., Sankaranarayanan K., Arumugam A., Green synthesis of gold nanoparticles from leaf extract of Terminalia arjuna, for the enhanced mitotic cell division and pollen germination activity, Industrial Crops and Products, 50, 2013. Crossref

  2. Devi Rethinam Sundaresan, Kist Manfred, Vani Ganapathy, Devi Chennam Srinivasulu Shyamala, Effect of methanolic extract of Terminalia arjuna against Helicobacter pylori 26695 lipopolysaccharide-induced gastric ulcer in rats, Journal of Pharmacy and Pharmacology, 60, 4, 2010. Crossref

  3. Paarakh Padmaa M, Terminalia arjuna (Roxb.) Wt. and Arn. : A Review, International Journal of Pharmacology, 6, 5, 2010. Crossref

  4. Kapoor Divya, Vijayvergiya Rajesh, Dhawan Veena, Terminalia arjuna in coronary artery disease: Ethnopharmacology, pre-clinical, clinical & safety evaluation, Journal of Ethnopharmacology, 155, 2, 2014. Crossref

  5. Further Reading, in Compendia of World's Medicinal Flora, 2006. Crossref

  6. Pawar R.S., Bhutani K.K., Effect of oleanane triterpenoids from Terminalia arjuna — a cardioprotective drug on the process of respiratory oxyburst, Phytomedicine, 12, 5, 2005. Crossref

  7. Devi Rethinam Sundaresan, Narayan Shoba, Vani Ganapathy, Shyamala Devi Chennam Srinivasulu, Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer, Chemico-Biological Interactions, 167, 1, 2007. Crossref

  8. Kaur Prabhjit, Chandel Madhu, Kumar Subodh, Kumar Neeraj, Singh Bikram, Kaur Satwinderjeet, Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens, Food and Chemical Toxicology, 48, 1, 2010. Crossref

  9. Cheng Hua-Yew, Lin Chun-Ching, Lin Ta-Chen, Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn., Antiviral Research, 55, 3, 2002. Crossref

  10. Miadoková Eva, Mašterová Irena, Vlčková Viera, Dúhová Viola, Tóth Jaroslav, Antimutagenic potential of homoisoflavonoids from Muscari racemosum, Journal of Ethnopharmacology, 81, 3, 2002. Crossref

  11. Rather Riyaz Ahmad, Malik Vivek Singh, Trikha Dimple, Bhat Owais, Dhawan Veena, AqueousTerminalia arjunaextract modulates expression of key atherosclerosis-related proteins in a hypercholesterolemic rabbit: A proteomic-based study, PROTEOMICS - Clinical Applications, 10, 7, 2016. Crossref

  12. Parveen Adila, Babbar Rashmi, Agarwal Sarita, Kotwani Anita, Fahim Mohammad, Terminalia arjuna Enhances Baroreflex Sensitivity and Myocardial Function in Isoproterenol-Induced Chronic Heart Failure Rats, Journal of Cardiovascular Pharmacology and Therapeutics, 17, 2, 2012. Crossref

  13. Allawadhi Prince, Khurana Amit, Sayed Nilofer, Kumari Preeti, Godugu Chandraiah, Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention, Phytotherapy Research, 32, 10, 2018. Crossref

  14. Kumar Ajay, Kaur Varinder, Pandit Kritika, Tuli Hardeep Singh, Sak Katrin, Jain Subheet Kumar, Kaur Satwinderjeet, Antioxidant Phytoconstituents From Onosma bracteata Wall. (Boraginaceae) Ameliorate the CCl4 Induced Hepatic Damage: In Vivo Study in Male Wistar Rats, Frontiers in Pharmacology, 11, 2020. Crossref

  15. Greco Giulia, Turrini Eleonora, Tacchini Massimo, Maresca Immacolata, Fimognari Carmela, The Alcoholic Bark Extract of Terminalia Arjuna Exhibits Cytotoxic and Cytostatic Activity on Jurkat Leukemia Cells, Venoms and Toxins, 1, 1, 2021. Crossref

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