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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Low Doses of Heavy Metals Disrupt Normal Structure and Function of Rat Platelets

Volume 20, Issue 1, 2001, 11 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.110
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ABSTRACT

Aggregation, an important property of platelets, plays a key role in the coagulation of blood and is potentiated by ADP and adrenaline, whereas cAMP acts as a strong inhibitor. Because of the rise in the heavy metal load in the environment, more studies are necessary to look at its subtle effects in the animal system, wherein platelet structure and function can be targeted. We carried out structural analyses under phase contrast and scanning electronmicroscopy of the platelets prepared from 1/10 LD50 metal-treated rats. After mercury (Hg) and arsenic (As) treatment, the cell margins appeared irregular and wavy, with small pseudopodia-like protrusions from the surface. Cadmium (Cd) treatment caused loss of the general spindle shape, and the platelets assumed a round spongy appearance. All metal treatments effected enhanced collagen-induced aggregation and inhibited ADP and arachidonic acid-induced aggregation, whereas epinephrine accelerated aggregation in Hg and Cd treatment but inhibited aggregation in As treatment. Cd proved a potent inhibitor of phosphodiesterase, increasing the cAMP level in in vitro treatments at equimolar (5, 10, and 20 pmoles) concentrations. The rate of aggregation was enhanced with all the agonists used in in vitro Hg and As treatments, with concomitant reduction in cAMP, while Cd inhibited platelet aggregation. Thus, we can conclude that cytosolic cAMP, which is decreased by the metal-induced inhibition of phosphodiesterase, is a regulator molecule in platelet aggregation. Furthermore, it is also abundantly clear that equimolar doses of metals are not always equitoxic. Therefore, the action of each xenobiotic is not only due to the concentration used but also to the type of xenobiotic depending on its unique mechanism of action.

CITED BY
  1. Nwokocha Chukwuemeka R., Baker Abena, Douglas Damion, McCalla Garsha, Nwokocha Magdalene, Brown Paul D., Apocynin Ameliorates Cadmium-Induced Hypertension Through Elevation of Endothelium Nitric Oxide Synthase, Cardiovascular Toxicology, 13, 4, 2013. Crossref

  2. González-Villalva Adriana, Piñón-Zárate Gabriela, De la Peña Díaz Aurora, Flores-García Mirthala, Bizarro-Nevares Patricia, Rendón-Huerta Erika P., Colín-Barenque Laura, Fortoul Teresa Imelda, The effect of vanadium on platelet function, Environmental Toxicology and Pharmacology, 32, 3, 2011. Crossref

  3. Virtanen Jyrki K., Rissanen Tiina H., Voutilainen Sari, Tuomainen Tomi-Pekka, Mercury as a risk factor for cardiovascular diseases, The Journal of Nutritional Biochemistry, 18, 2, 2007. Crossref

  4. Gonzalez-Villalva Adriana, Bizarro-Nevares Patricia, Rojas-Lemus Marcela, Ustarroz-Cano Martha, López-Valdez Nelly, García-Peláez Isabel, Albarrán-Alonso Juan Carlos, Barbosa-Barrón Fernanda, Fortoul Teresa I, A brief review of the biology of megakaryocytes and platelets and their role in thrombosis associated with particulate air pollution, Toxicology and Industrial Health, 37, 3, 2021. Crossref

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