Abonnement à la biblothèque: Guest
International Heat Transfer Conference 13
Graham de Vahl Davis (open in a new tab) School of Mechanical and Manufacturing Engineering, University of New South Wales, Kensington, NSW, Australia
Eddie Leonardi (open in a new tab) Computational Fluid Dynamics Research Laboratory, School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, Australia 2052

ISSN Online: 2377-424X

ISBN CD: 1-56700-226-9

ISBN Online: 1-56700-225-0

OXYGEN TRANSFER IN THE CEREBRAL TISSUE

page 12
DOI: 10.1615/IHTC13.p30.300
Get accessGet access

RÉSUMÉ

Oxygen delivery in the brain tissue is carried out by a convective-diffusion process determined by spatial inhomogeneity of partial pressure of oxygen (pO2). Previous studies identified inhomogeneous distribution of cerebral tissue pO2, which is related to spatial variations in microvascular structure, because large amount of oxygen is supplied from microvascular network. In this study, to evaluate the oxygen transport in cerebral cortex, we focused on regional structure of microvascular network and pO2 distribution in rat somatosensory cortex. To this end, firstly, we quantified three-dimensional microvascular structure by using confocal laser-scanning microscope (CLSM). Secondly, we characterized local tissue pO2 distribution by using an oxygen microelectrode. Finally, we discussed the possible feature of oxygen transfer in the cerebral tissue by numerical simulation of convective-diffusive process based on these experimental data (i.e., pO2 distribution and microvascular structure).

Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain