RT Journal Article ID 6bdd0cdf26664de5 A1 Barneche, Stephanie A1 Alborés, Silvana A1 Borthagaray, Graciela A1 Cerdeiras, María Pía A1 Vázquez, Alvaro T1 Anti-MRSA Activity of Fruiting Body Extracts of Spectacular Rustgill Mushroom, Gymnopilus junonius (Agaricomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2017 FD 2017-05-05 VO 19 IS 3 SP 243 OP 248 K1 bacterial resistance K1 medicinal mushrooms K1 Staphylococcus aureus K1 Gymnopilus junonius AB Despite the great advances in chemotherapeutics, infectious diseases are still one of the leading causes of death worldwide. Among some of the clinically relevant pathogens, methicillin-resistant Staphylococcus aureus (MRSA) ranks as one of the most difficult bacteria to treat. It is a common cause of skin, soft-tissue, and endovascular infections, as well as pneumonia, septic arthritis, endocarditis, osteomyelitis, and sepsis. The research on Basidiomycota is extensive; many species show a broad spectrum of pharmacological activities, including antimicrobial activity. The vast majority of the literature to date generally focuses on screening the antibacterial properties of mushroom extracts. A gap still exists in the identification of the individual compounds responsible for these properties, and few low molecular weight compounds have been described. Gymnopilus junonius, the big laughter mushroom, grows wild in Uruguay, especially on Eucalyptus spp. plantations; it is known as the "eucalyptus fungus." In this work, we report the bioguided isolation, structural elucidation, and antistaphylococcal activity of the main antimicrobial components of fresh basidiocarps of G. junonius. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2660055b0a219fef,6bdd0cdf26664de5.html