RT Journal Article
ID 66e7cdbc680b0d6a
A1 Sharma, K. V.
A1 Singh, Umang
A1 Vats, Sharad
A1 Priyadarsini, K. I.
A1 Bhatia, A. L.
A1 Kamal, Raka
T1 Evaluation of Evidenced-Based Radioprotective Effi cacy of Gymnema sylvestre Leaves in Mice Brain
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2009
FD 2010-01-22
VO 28
IS 4
SP 311
OP 323
K1 Gymnema sylvestre
K1 DPPH• scavenging assays
K1 superoxide radical scavenging assays
K1 protein carbonyl estimation assay
K1 pulse radiolysis
K1 mice brain
K1 in vivo studies
AB A Gymnema sylvestre leaves extract (GSE) rich in gymnemic acids was examined for its antioxidant activities through various in vitro assays, along with its radioprotective efficacy in mice brain. The IC50 values of GSE for 2,2-diphenyl-1-picrylhydrazyl scavenging assays, superoxide radical scavenging assays, inhibition of in vitro lipid peroxidation assays, and protein carbonyl formation assay were 238, 140, 99.46, and 28.03 μg/mL, respectively. Furthermore, the total phenolic content in GSE was equivalent to 18.06 μg/mL of Gallic acid. The rate of •OH radical scavenging activity of GSE is 0.46 times slower than SCN− derived from nanosecond pulse radiolysis studies. Results of in vivo studies showed that radiation (8 Gy)-induced augmentation in the levels of lipid peroxidation and depletion in glutathione and protein levels in mice brain were significantly ameliorated by GSE pretreatment. Results suggest that the radioprotective effi cacy of GSE may be due to its antioxidant properties.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,53151bb00a708171,66e7cdbc680b0d6a.html