RT Journal Article ID 6640aef759eda28b A1 Zhao, Qinyi T1 Protein Flexibility as a Biosignal JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2010 FD 2010-12-04 VO 20 IS 2 SP 157 OP 170 K1 protein flexibility K1 protein structure-function relationship K1 signaling K1 hydrophobicity K1 temperature AB Dynamic properties of a protein are crucial for all protein functions, and those of signaling proteins are closely related to the biological function of living beings. The protein flexibility signal concept can be used to analyze this relationship. Protein flexibility controls the rate of protein conformational change and influences protein function. The modification of protein flexibility results in a change of protein activity. The logical nature of protein flexibility cannot be explained by applying the principles of protein three-dimensional structure theory or conformation concept. Signaling proteins show high protein flexibility. Many properties of signaling can be traced back to the dynamic natures of signaling protein. The action mechanism of volatile anesthetics and universal cellular reactions are related to flexibility in the change of signaling proteins. We conclude that protein dynamics is an enzyme-enhanced process, called dynamicase. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,4755276625828a95,6640aef759eda28b.html