RT Journal Article ID 620ef30e1469bb4a A1 Farooq, Tahir A1 Hameed, Arruje A1 Rehman, Kanwal A1 Ibrahim, Muhammad A1 Qadir, Muhammad Imran A1 Akash, Muhammad Sajid Hamid T1 Antiretroviral Agents: Looking for the Best Possible Chemotherapeutic Options to Conquer HIV JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2016 FD 2016-11-03 VO 26 IS 4 SP 363 OP 381 K1 synthetic anti-HIV drugs K1 protease inhibitors K1 potent natural anti-HIV agents AB For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to chronic conditions. However, many challenges, like emergence of drug resistance, limited the scope of activity of currently existing anti-HIV agents. Quite often severe side effects and lifelong dependency are the major concerns of present era. All these issues have compelled the scientists to reconsider and refine the current therapies and also contemplate the pivotal priorities for the developments of novel therapeutic paradigms. In response to this global concern, medicinal chemists and pharmaceutical scientists have put in solid efforts to search for or develop novel, more effective, safer, and affordable antiretroviral agents for the treatment of HIV infections. The exploration and utilization of natural sources has always been an attractive research area in this regard. In the search of the most suitable and potent anti-HIV agents, researchers have explored the anti-HIV activity of different classes of compounds originating from plants, marine organisms, and microorganisms. This review will highlight the recent notable developments for the discovery of antiretroviral agents. Furthermore, this review also highlights the better in-depth insights of existing HIV cures and preventive strategies. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,73c57fd25a6798d9,620ef30e1469bb4a.html