RT Journal Article ID 59357d602b896237 A1 Ohno, Naohito T1 Structural Diversity and Physiological Functions of β-Glucans JF International Journal of Medicinal Mushrooms JO IJM YR 2005 FD 2005-05-03 VO 7 IS 1&2 SP 167 OP 174 AB This article provides an overview of the structures and biological activities of β-glucans (BGs), focusing primarily on results that we obtained. BGs demonstrate a diverse range of biological activities, and this diversity is so great that a "common activity" has not been identified to this day. Although which activity is truly significant should probably be determined from the viewpoint of the effective use of BGs, one of the characteristics of BGs being "broad spectrum," it is expected that future research will be conducted to clarify this matter. In addition, BGs are present in large amounts in the environment, and it was found that humans and animals not only react to BGs in the form of innate immunity, but also recognize BGs via acquired immunity. This suggests that it is necessary to expand and revise the conventional mechanism of action associated with BGs in order to develop a new mechanism of action. BGs consist of both "old" and "new" materials. When immunoregulation is considered, there is the question of whether recently discovered cytokines, gene therapy, or cancer vaccines may serve as substitutes for BGs. It is preferable that all of these be allowed to coexist. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2cbf07a603004731,59357d602b896237.html