RT Journal Article
ID 546bf4df63a3f7c7
A1 Ertan, Yesim
A1 Argon, Asuman
A1 Özdemir, Murat
A1 Yürekli, Banu Pınar Sarer
A1 Dökümcü, Zafer
A1 Makay, Özer
T1 Oncocytic Adreno Cortical Tumors: Pathological Features of 16 Cases and Review of the Literature
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2017
FD 2017-12-22
VO 36
IS 3
SP 237
OP 244
K1 oncocytic adrenocortical tumor
K1 oncocytoma
K1 adrenal cortical tumor
K1 adrenal cortical tumor with uncertain malignant potential
K1 pediatric adrenocortical tumor.
AB Oncocytic neoplasms of the adrenal gland are extremely rare tumors. These tumors differ from their nononcocytic counterparts in some respects. The aim of this study was to review and discuss the clinical, histological, and immunohistochemical features of as well as the prognosis for these rare tumors.
In total, 16 cases diagnosed as adrenocortical oncocytic neoplasms between January 2011 and December 2016
were included in the study. The demographic data, gross characteristics, histological data, and immunohistochemical
data (Chromogranin-A, Synaptophysin, α-Inhibin, Melan-A, Ki67, PHH3) were reevaluated. The follow-up data for
these patients were added in January 2017.
Of the 16 cases, 12 were adrenocortical adenoma, 1 was borderline adrenocortical tumor, and 3 were adrenocortical
carcinoma. The tumors equally affected both genders. The tumors were not generally large. Tumor cells had
pleomorphic nuclei in ten cases, but it was more obvious in one case. The mitotic figure count was low in most tumors.
Atypical mitosis and necrosis were observed in three and four tumors, respectively. None of cases included sinusoidal
invasion, vascular invasion, or capsular invasion. We detected the expression of at least one specific marker (e.g., Melan-A, Inhibin-α) of the adrenal cortex in all tumors. None of the tumors were immunoreactive for Chromogranin-A. Ki-67 proliferation index was lower than 5% in all cases except three oncocytic carcinomas. In two cases, PHH3 positivity was not seen, while it was lower than 3 of 10 high-powered fields in ten cases and higher in 4 cases. All patients were alive and disease free except for two patients with adrenocortical carcinoma.
In conclusion, determining the clinical, histological, and immunohistochemical characteristics of these extremely rare
tumors can provide important information for early diagnosis, treatment, and follow-up of these cases.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1828aa871383557b,546bf4df63a3f7c7.html