RT Journal Article
ID 540259e960df436e
A1 Garg, Tarun
A1 Singh, Simranjit 
A1 Goyal, Amit
T1 Stimuli-Sensitive Hydrogels: An Excellent Carrier for Drug and Cell Delivery
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2013
FD 2013-10-04
VO 30
IS 5
SP 369
OP 409
K1 stimuli-sensitive hydrogels
K1 tissue engineering
K1 drug delivery
K1 gene delivery
K1 photolithography
AB The stimuli-sensitive hydrogel is an injectable formulation that is used to deliver drugs, cells, and genes into the body. Hydrogels are available in various physical forms such as solid molded, pressed powder matrix, microparticle, coating, or membrane forms. The network structure of hydrogels can be macroporous, microporous, or nonporous. Different categories of biomaterials, such as natural, synthetic, and combinations (e.g., semisynthetic such as natural-natural, natural-synthetic, and synthetic-synthetic polymers), are commonly used in hydrogel preparation. Classification of hydrogels mainly depends upon physical stimuli (temperature, electric fields, solvent composition, light, pressure, sound, and magnetic fields) and chemical or biochemical stimuli (pH, ions, and specific molecular recognition events). Several approaches for the synthesis of hydrogels have been reported, including emulsification, micromolding, photolithography, isostatic ultra high pressure, and microfluidic techniques. Hydrogels provide structural integrity and cellular organization, serve as tissue barriers, act as bioadhesive and drug depots, deliver bioactive agents and cells, and possess unique swelling properties and structures. This review provides a detailed account of the need for development of hydrogels, along with the materials used and techniques adopted to manufacture scaffolds for tissue engineering and for prolonged drug, cell, and gene delivery.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,008474ee60c087bc,540259e960df436e.html