RT Journal Article ID 4ba191eb4578ed4d A1 Chien, Rao-Chi A1 Lin, Lan-Min A1 Chang, Yuan-Hua A1 Lin, Yu-Chieh A1 Wu, Pei-Hsuan A1 Asatiani, Mikheil D. A1 Wasser, Sophie-Gabrielle A1 Krakhmalnyi, Maxim A1 Agbarya, Abed A1 Wasser, Solomon P. A1 Mau, Jeng-Leun T1 Anti-Inflammation Properties of Fruiting Bodies and Submerged Cultured Mycelia of Culinary-Medicinal Higher Basidiomycetes Mushrooms JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-12-20 VO 18 IS 11 SP 999 OP 1009 K1 flavonoids K1 fruiting body K1 inflammation K1 medicinal mushrooms K1 mycelium K1 phenols AB This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts. Overall, Cordyceps militaris fruiting bodies, Grifola frondosa fruiting bodies, and Ophiocordyceps sinensis mycelia might be used to ameliorate inflammatory responses. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,07a0495239bddf76,4ba191eb4578ed4d.html