RT Journal Article ID 25f63c9a2c43158e A1 Metsebing, Blondo-Pascal A1 Oba, Romuald A1 Mossebo, Dominique Claude A1 Fonkui, Thierry Youmbi A1 Tsigain, Fabrice Tsigaing A1 Fotsing, Marthe Carine Djuidje A1 Mungoh, Tata Charlotte A1 Ndinteh, Derek Ntantoh T1 Comparative Assessment of Antifungal and Antibacterial Activities of Crude Extracts of the King Tuber Culinary-Medicinal Mushroom, Pleurotus tuber-regium (Agaricomycetes) from Cameroon JF International Journal of Medicinal Mushrooms JO IJM YR 2020 FD 2020-05-11 VO 22 IS 4 SP 359 OP 366 K1 Agaricomycetes K1 medicinal mushrooms K1 P. tuber-regium K1 carpophore K1 sclerotium K1 antimicrobial activity AB Antifungal and antibacterial activities of crude extracts of carpophore compared with those of sclerotium of Pleurotus tuber-regium were investigated on 11 species of bacterial and 3 fungal human pathogens. The minimal inhibitory concentration (MIC) of carpophore extract was recorded to be 12.5 mg/mL on Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Escherichia cloacae, Proteus mirabilis, P. vulgaris, Klebsiella oxytoca, and K. aerogenes and 6.25 mg/mL on Staphylococcus aureus, Escherichia coli, and Mycobacterium smegmatis as well as on all three species of fungal pathogens including Candida albicans, Aspergillus fumigatus, and A. ochraceus. In comparison, the MIC of sclerotium was recorded to be 12.5 mg/mL on Bacillus subtilis and Klebsiella aerogenes; 6.25 mg/mL on Enterococcus faecalis, Staphylococcus aureus, S. epidermidis, Enterobacter cloacae, E. coli, Mycobacterium smegmatis, Proteus mirabilis, P. vulgaris, and Klebsiella oxytoca; and 3.13 mg/mL on the three fungal pathogens. Based on the abovementioned figures, it appears that strains of pathogenic fungi tested are much more sensitive to crude extracts than the abovementioned bacteria. In fact, antimicrobial activities of crude extracts of P. tuber-regium, no matter whether it is that of the carpophore or its sclerotium, are in general stronger on human pathogenic fungi than bacteria. These figures also demonstrate that crude extracts of sclerotium show a higher antimicrobial activity than that of carpophore. Carpophores and sclerotia of P. tuber-regium could therefore constitute a source of new molecules potentially more efficient than synthetic products against some human pathogenic fungi and bacteria. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,742ee6254aa2c7db,25f63c9a2c43158e.html