RT Journal Article ID 1e643e756a38a3d3 A1 Cavalieri, Filippo T1 Drugs That Target Gene Expression: An Overview JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1996 FD 1996-03-30 VO 6 IS 1 SP 75 OP 85 K1 signal transduction K1 transcriptional modulation K1 dug discovery K1 high throughput screening K1 automation K1 whole cell assay K1 sickle cell anemia. AB Over the last few years, it has become apparent that regulation of many normal physiological pathways, as well as the response to a wide variety of disease states, involves specific changes in gene transcription. The concept of drugs that regulate gene transcription is now firmly established. There are multiple, highly effective drugs in widespread use whose primary mechanism of action is to affect gene transcription. A major goal at Oncogene Science is to develop drugs that can modulate the normal physiological responses associated with disease by specifically increasing or decreasing the transcription of key genes. In this article, we review several examples of drugs that have been shown to act by regulating gene transcription and describe the approach Oncogene Science has pioneered. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,4e5dc78f6cfef1b9,1e643e756a38a3d3.html