RT Journal Article
ID 1a3b96cc6d69b527
A1 Lee, Shinrye 
A1 Jha, Mithilesh Kumar 
A1 Suk, Kyoungho 
T1 Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes
JF Critical Reviews™ in Immunology
JO CRI
YR 2015
FD 2015-02-20
VO 35
IS 1
SP 77
OP 84
K1 lipocalin-2
K1 astrocytes
K1 neuroinflammation
K1 central nervous system
K1 chemokine
K1 polarization
AB Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration. Recently, we reported that LCN2 is secreted by brain astrocytes under inflammatory conditions and that it promotes apoptosis, morphological changes, and migration in astrocytes both in vitro and in vivo. Activated astrocytes release LCN2 not only to induce the morphological transformation associated with reactive astrocytosis, but also to promote their own death. Under inflammatory conditions, activated astrocytes also show functional dichotomy similar to the M1/M2 phenotypes of microglia and macrophages. LCN2 is thought to be a chemokine inducer and an autocrine promoter of the classical proinflammatory activation of astrocytes. This article summarizes the current knowledge regarding the role of astrocyte-derived LCN2 as a proinflammatory mediator in the central nervous system and discusses LCN2's role in neuroinflammatory disorders.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,59d3fecb4dbb6d4a,1a3b96cc6d69b527.html