RT Journal Article ID 019719905f30f29f A1 Morshed, Bashir I. A1 Shams, Maitham A1 Mussivand, Tofy T1 Electrical Lysis: Dynamics Revisited and Advances in On-chip Operation JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2013 FD 2013-03-07 VO 41 IS 1 SP 37 OP 50 K1 cell membrane K1 electric field K1 electrical lysis K1 electroporation K1 microfluidics K1 on-chip operation AB Electrical lysis (EL) is the process of breaking the cell membrane to expose the internal contents under an applied high electric field. Lysis is an important phenomenon for cellular analysis, medical treatment, and biofouling control. This paper aims to review, summarize, and analyze recent advancements on EL. Major databases including PubMed, Ei Engineering Village, IEEE Xplore, and Scholars Portal were searched using relevant keywords. More than 50 articles published in English since 1997 are cited in this article. EL has several key advantages compared to other lysis techniques such as chemical, mechanical, sonication, or laser, including rapid speed of operation, ability to control, miniaturization, low cost, and low power requirement. A variety of cell types have been investigated for including protoplasts, E. coli, yeasts, blood cells, and cancer cells. EL has been developed and applied for decon-tamination, cytology, genetics, single-cell analysis, cancer treatment, and other applications. On-chip EL is a promising technology for multiplexed automated implementation of cell-sample preparation and processing with micro- or nanoliter reagents. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,466a37f746795863,019719905f30f29f.html