RT Journal Article
ID 00a003820045a16e
A1 Chorny, Michael
A1 Fishbein, Ilia
A1 Golomb, Gershon
T1 Drug Delivery Systems for the Treatment of Restenosis
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2000
FD 2000-06-01
VO 17
IS 3
OP 36
AB Attempts to achieve revascularization of coronary arteries blocked by atherosclerotic plaques are hampered by restenotic hyperproliferative response of die treated vessels. The uniform failure of clinical trials using systemic therapies to prevent restenosis has prompted development of methods for arterial drug delivery systems. This review describes technologies of polymeric-based, perivascular, and intraluminal drug and gene delivery systems. The critical assessment of controversies including drug and vehicle type, dose and release rate, and preclinical validation is reviewed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,7461ea3e4c45d3e6,00a003820045a16e.html