RT Journal Article
ID 0092270b77a07187
A1 Wang, Junzhi
A1 Lv, Huifang
A1 Chen, Beiyan
A1 Huang, Wenfeng
A1 Wang, Ailing
A1 Liu, Lanqing
A1 He, Haibo
A1 Chen, Jianfeng
A1 Li, Shi
A1 Deng, Wei-Qiao
T1 Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2019
FD 2019-04-11
VO 21
IS 4
SP 381
OP 392
K1 methyl-hispolon
K1 estrogen signals
K1 phytoestrogen
K1 hormone replacement therapy
K1 Phellinus lonicerinus
K1 medicinal mushrooms
AB We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6.68 kcal/mol in docking simulations. Methyl-hispolon had a significant antiproliferative effect for estrogen-sensitive ER(+) MCF-7 cells in the absence of estrogen, and it exhibited dual estrogen activities. Methyl-hispolon increased the serum E2 in rats with premature ovarian failure and fulfilled the estrogenic function in the uterus and ovary. Methyl-hispolon significantly inhibited the expression of Ras, API, ERα, C-myc, and cyclinDl, as well as their gene transcription in RL95-2 cells. The phosphorylation of ERK1/2 was inhibited by methyl-hispolon. Thus, methyl-hispolon has potential use in treating estrogen deficiency-related diseases, with good antitumor effects and estrogenic activity.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2b9ba90674ebcc50,0092270b77a07187.html