Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Fluid Mechanics Research
ESCI SJR: 0.206 SNIP: 0.446 CiteScore™: 0.5

ISSN Imprimer: 2152-5102
ISSN En ligne: 2152-5110

Volumes:
Volume 47, 2020 Volume 46, 2019 Volume 45, 2018 Volume 44, 2017 Volume 43, 2016 Volume 42, 2015 Volume 41, 2014 Volume 40, 2013 Volume 39, 2012 Volume 38, 2011 Volume 37, 2010 Volume 36, 2009 Volume 35, 2008 Volume 34, 2007 Volume 33, 2006 Volume 32, 2005 Volume 31, 2004 Volume 30, 2003 Volume 29, 2002 Volume 28, 2001 Volume 27, 2000 Volume 26, 1999 Volume 25, 1998 Volume 24, 1997 Volume 23, 1996 Volume 22, 1995

International Journal of Fluid Mechanics Research

DOI: 10.1615/InterJFluidMechRes.2017016597
pages 79-92

ASSESSMENT OF ACCUMULATION RATE OF LDL SPECIES IN ARTERIAL WALL LAYERS UNDER HYPERTENSION AND HYPERLIPIDEMIA CONDITIONS

Somnath Santra
Department of Mechanical Engineering, Indian Institute of Engineering Science and Technology, Shibpur, Howrah - 711103, West Bengal, India
Dipak Kumar Mandal
Deptartment of Mechanical Engineering, College of Engineering & Management, Kolaghat, P.O: K.T.P.P. Township, Midnapore (E) - 721171, West Bengal, India
Somnath Chakrabarti
Department of Mechanical Engineering, Indian Institute of Engineering Science and Technology Shibpur, Howrah, 711103, West Bengal, India

RÉSUMÉ

In this study, a numerical model has been developed for implementing the convective and diffusive transport of LDL cholesterol in multilayered arterial wall. A new conceptual approach has also been done in order to estimate the LDL deposition rate in arterial layers under hyper-tension and hyper-lipidemia conditions considering the non-Newtonian nature of blood. The arterial wall layers viz. endothelium, intima, internal elastic lamina (IEL) and media are assumed to be homogeneous porous media. The Navier-Stokes equation and Darcy's equation have been used for representing the fluid flow in the lumen and the arterial wall, respectively. The mass transport in the lumen has been modeled through the convection-diffusion equation, whereas volume-averaged convection-diffusion-reaction equation has been used for simulating the mass transport through porous layers. This paper shows that the rate of accumulation is higher in intima layer than the media layer and also pointed out that the intima layer is a possible layer of initiation of the disease and that the endothelium provides a maximum barrier to solute flow across it. Thus, any denudation that occurred in endothelium may enhance the possibility of the formation of the disease. Finally, the paper shows that among the considered clinical parameters (hypertension and hyperlipidemia), hypertension is more vulnerable to the possible occurrence of the disease.