Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
The Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) Substances Interfere with H2O2 Induction of the NF-κB Pathway through Inhibition of IκBα Phosphorylation in MCF7 Breast Cancer Cells
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RÉSUMÉ
Breast cancer is the most commonly diagnosed cancer among women. Currently, there is no effective therapy for malignant estrogen-independent breast cancer. In our study, we used hydrogen peroxide, a well-known strong oxidative reagent capable of activating the nuclear factor kappa B (NF-κB) transcription factor. The IC50 value of the culinary-medicinal Shaggy Inc Cap mushroom Coprinus comatus culture liquid crude extract on MCF7 cell viability was found to be as low as 76 μg/mL, and the IC50 value of C. comatus ethyl acetate extract was only 32 μg/ mL. Our results also showed that both extracts significantly affected IκBα phosphorylation in a dose-dependent manner. The effect of ethyl acetate extract was comparable to the effect of curcumin, a known NF-κB pathway inhibitor, and seemed to be the most active inhibitor of H2O2-dependent IκBα phosphorylation. In addition, the data obtained showed that only ethyl acetate extract inhibited the activity of IKK complex, at close to 90% as compared to the control of the untreated sample. These results suggest that C. comatus contains potent compounds capable of inhibiting NF-κB function and also possibly acts as an antitumor agent.
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Zeng Ya-Wen, Yang Jia-Zheng, Pu Xiao-Ying, Du Juan, Yang Tao, Yang Shu-Ming, Zhu Wei-Hua, Strategies of Functional Food for Cancer Prevention in Human Beings, Asian Pacific Journal of Cancer Prevention, 14, 3, 2013. Crossref
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Patel Seema, Goyal Arun, Recent developments in mushrooms as anti-cancer therapeutics: a review, 3 Biotech, 2, 1, 2012. Crossref
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Stajić Mirjana, Vukojević Jelena, Ćilerdžić Jasmina, Mushrooms as Potential Natural Cytostatics, in Medicinal Mushrooms, 2019. Crossref
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Nowakowski Patryk, Naliwajko Sylwia K., Markiewicz‐Żukowska Renata, Borawska Maria H., Socha Katarzyna, The two faces of Coprinus comatus —Functional properties and potential hazards , Phytotherapy Research, 34, 11, 2020. Crossref
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Fedotov O. V. , Phenolic substances as regulators of the intensity of lipid peroxidation processes of the strains Pleurotus eryngii, Fistulina hepatica and Agrocybe cylindracea , Regulatory Mechanisms in Biosystems, 11, 2, 2020. Crossref
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Ren Jun, Shi Jin-Li, Han Chun-Chao, Liu Zhen-Quan, Guo Jian-You, Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus , BMC Complementary and Alternative Medicine, 12, 1, 2012. Crossref
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Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref
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Panda Mrunmaya K., Paul Manish, Singdevsachan Sameer K., Tayung Kumananda, Das Swagat K., Thatoi Hrudayanath, Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions, Current Pharmaceutical Biotechnology, 22, 9, 2021. Crossref
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Wang Yiwei, Yu Jiayi, Cui Ran, Lin Jinjin, Ding Xianting, Curcumin in Treating Breast Cancer: A Review, SLAS Technology, 21, 6, 2016. Crossref
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Hamad Doaa, El-Sayed Heba, Ahmed Wafaa, Sonbol Hana, Ramadan Mohammed Abdel Halim, GC-MS Analysis of Potentially Volatile Compounds of Pleurotus ostreatus Polar Extract: In vitro Antimicrobial, Cytotoxic, Immunomodulatory, and Antioxidant Activities, Frontiers in Microbiology, 13, 2022. Crossref
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Figueiredo Lélia, Régis Wiliam César Bento, Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action, Nutrire, 42, 1, 2017. Crossref
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Ray Ribhu, Saha Saparja, Paul Santanu, Two novel compounds, ergosterol and ergosta-5,8-dien-3-ol, from Termitomyces heimii Natarajan demonstrate promising anti-hepatocarcinoma activity, Journal of Traditional Chinese Medical Sciences, 9, 4, 2022. Crossref