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International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2020033990
pages 325-333

Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on β-Amyloid-Induced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies

Chun-Jing Zhang
Department of Biochemistry, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China
Jian-You Guo
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Hao Cheng
Third Affiliated Hospital, Qiqihar Medical University Qiqihar 161006, Heilongjiang, China
Li Lin
Department of Clinical Biochemistry, Qiqihar Medical University Qiqihar 161006, Heilongjiang, China
Ying Liu
Department of Biochemistry, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China
Yan Shi
Department of Biochemistry, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China
Jing Xu
Department of Biochemistry, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China
Hai-Tao Yu
Department of Biology Genetics, Qiqihar Medical University Qiqihar 161006, Heilongjiang, China

RÉSUMÉ

Pleurotus eryngii (PE) contains polysaccharides and vitamins, and has been reported to have antidepression properties. P. eryngii polysaccharides (PEP) are one of the main components. Modulation of β-amyloid-induced neurotoxicity has emerged as a possible therapeutic approach to ameliorate the onset and progression of Alzheimer's disease (AD). The present study aimed to evaluate the protective effect of PEP on β-amyloid-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells and aging rats. After 28 weeks' treatment, exposure of PC12 cells to P. eryngii polysaccharides significantly elevated cell viability, decreased the levels of intracellular calcium, and attenuated the β-amyloid-mediated cell apoptosis. In aging rats, P. eryngii polysaccharides could decrease the production of APP in the brain by an action that is associated with a lowering of the iNOS, and COX-2 level. Our findings indicated that P. eryngii polysaccharides had potential neuroprotective actions against β-amyloid-induced neurotoxicity, which might be through modulating calcium channels, or downstream molecules involved in inflammation.

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