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International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2020034223
pages 389-396

Ergosterol Peroxide from the Egyptian Red Lingzhi or Reishi Mushroom, Ganoderma resinaceum (Agaricomycetes), Showed Preferred Inhibition of MCF-7 over MDA-MB-231 Breast Cancer Cell Lines

Neveen F. El-Sherif
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Safwat A. Ahmed
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Amany K. Ibrahim
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Eman S. Habib
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Amira A. El-Fallal
Botany and Microbiology Department, Faculty of Science, Damietta University, New Damietta City, Egypt
Ahmed K. El-Sayed
Botany and Microbiology Department, Faculty of Science, Damietta University, New Damietta City, Egypt
Amir E. Wahba
Chemistry Department, Faculty of Science, Damietta University, New Damietta City, Egypt; Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA

RÉSUMÉ

Ergosterol peroxide and ganoderic acid AMI were isolated for the first time from the mycelium of the Egyptian Ganoderma resinaceum mushroom. The structure of these two metabolites was established by detailed analysis of 1D and 2D NMR. The isolated compounds were tested for their antitumor in vitro activities in MCF-7 and MDA-MB-231 breast cancer cell lines. Ergosterol peroxide showed preferred inhibition of MCF-7 (ER +ve) cell lines relative to MDA-MB-231 (ER -ve) cell lines with an IC50 of 1.18 μM and 12.82 μM respectively. Our data suggest that ergosterol peroxide targets estrogen receptors.

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