Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
New Scientific Approaches to Cancer Treatment: Can Medicinal Mushrooms Defeat the Curse of the Century?
RÉSUMÉ
Modern science has spread so broadly and deeply within the nature of organisms that researchers have already established the molecular mechanisms of each vital process of human existence. Unfortunately, our age, heredity, lifestyle, race, and ethnicity are directly connected to the development and expression of many negative and even fatal processes, such as carcinogenesis. Many investigators have shown that the roots of carcinogenesis are hidden in the signaling pathways of cancer cells. Therefore, the pharmacological modulation of intracellular signal transduction pathways and the activation of transcription factors regulating gene expression represent a new and attractive therapeutic approach to cancer. It is already well established that medicinal mushrooms represent a potential source for biologically active compounds with immunomodulating, free radical scavenging, anti-inflammatory, antibacterial, antifungal, antiviral, hepatoprotective, antidiabetic, and anticancer activities. Moreover, low−molecular weight mushroom substances have been studied, and reported to interact with particular intracellular signaling pathways related to processes such as inflammation, cell differentiation and survival, apoptosis, angiogenesis, tumor progression and metastasis, etc. The present work compiles the available data on mushroom substances, in the form of extracts or chemically defined compounds, known to interfere with the above-mentioned essential processes related to the carcinogenesis and, thus, representing a new scientific approach to cancer treatment and prevention.
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De Silva Dilani D., Rapior Sylvie, Sudarman Enge, Stadler Marc, Xu Jianchu, Aisyah Alias S., Hyde Kevin D., Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry, Fungal Diversity, 62, 1, 2013. Crossref
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Tian Li, Wang Xiaoli, Li Xingyun, Liu Ben, Zhang Wei, Cao Jing, Ning Anhong, Huang Min, Zhong Mintao, In vitro antitumor activity of Latcripin-15 regulator of chromosome condensation 1 domain protein, Oncology Letters, 12, 5, 2016. Crossref
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Gulfishan Mohd, Afzal Muhammad, Kazmi Imran, Quazi Anwarulabedin Mohsin, Bhat Tariq Ahmad, Jahan Ajmat, Mechanism of Action of Anticancer Herbal Medicines, in Anticancer Plants: Mechanisms and Molecular Interactions, 2018. Crossref
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Younis Ahmed M., Yosri Mohamed, Stewart Jennifer K., In vitro evaluation of pleiotropic properties of wild mushroom Laetiporus sulphureus, Annals of Agricultural Sciences, 64, 1, 2019. Crossref
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Dasgupta Adhiraj, Acharya Krishnendu, Mushrooms: an emerging resource for therapeutic terpenoids, 3 Biotech, 9, 10, 2019. Crossref
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Singh S.K., Jadon K.S., Pathak Rakesh, Prospective of macrofungal metabolites in human health, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref