Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Immunopotentiating Properties of Lentinan (1®3)-b-D-glucan Extracted from Culinary–Medicinal Shiitake Mushroom Lentinus edodes (Berk.) Singer (Agaric
RÉSUMÉ
The immunopotentiating efficacy of lentinan, a fully purified (1®3)-b-D-glucan extracted from culinary–medicinal mushroom Lentinus edodes (Berk.) Singer was investigated both in vitro and in vivo. The oral administration of lentinan to AKR mice exerted strong antitumor activity, resulting in raised levels of lymphocytokines such as IFN-g, TNF-a, IL-2, and IL-1a. Tissue cultures of murine macrophages CRL-2019, B-lymphocytes HB-284, and T-lymphocytes CRL-8179, which were treated with lentinan, showed high levels of activation using flow cytometry. Activated immunocytes, particularly the T-helper cells by lentinan, might render the physiological constitutions of the host highly cancer and infection resistant. Adoptive immunotherapy of the immunodeficient mice such as the nude (athymic) mice, B-cell deficient mice, and SCID (severe combined immunodeficient) mice via the transfer of the lentinan-activated immunocytes resulted in the inhibition of tumor growth. Lentinan appeared to represent a unique class of host defense potentiators (HDP), protecting the hosts from the side effects of conventional therapeutic measures and improving various kinds of immunological parameters with no toxic side-effects in animal models.
-
Kim Jong-Soo, Choi Dubok, Jung Bock-Gie, Lee Bong-Joo, Lim Geum-Sook, Lee Myung Koo, Cha Wol-Suk, Cho Hoon, Effects of fruiting body extracts of Lentinus edodes cultivated using corn cob on biological activities, Korean Journal of Chemical Engineering, 30, 4, 2013. Crossref
-
Ulbricht Catherine, An Evidence-Based Systematic Review of Beta-Glucan by the Natural Standard Research Collaboration, Journal of Dietary Supplements, 11, 4, 2014. Crossref
-
Moradali Mohammad-Fata, Mostafavi Hossein, Ghods Shirin, Hedjaroude Ghorban-Ali, Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi), International Immunopharmacology, 7, 6, 2007. Crossref
-
Rastall R.A., Diez-Municio M., Forssten S.D., Hamaker B., Meynier A., Moreno F. Javier, Respondek F., Stah B., Venema K., Wiese M., Structure and function of non-digestible carbohydrates in the gut microbiome, Beneficial Microbes, 13, 2, 2022. Crossref
-
You Hong, Abraham Evelyn J., Mulligan Jason, Zhou Yucheng, Montoya Maureen, Willig Jennifer, Chen Bo-Kai, Wang Chin-Kun, Wang Li-Shu, Dong Athena, Shamtsyan Mark, Nguyen Haiuyen, Wong Andrea, Wallace Taylor C., Label compliance for ingredient verification: regulations, approaches, and trends for testing botanical products marketed for “immune health” in the United States, Critical Reviews in Food Science and Nutrition, 2022. Crossref