Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i3.50
pages 277-286

Aqueous Extracts of Cordyceps militaris (Ascomycetes) Lower the Levels of Plasma Glucose by Activating the Cholinergic Nerve in Streptozotocin-Induced Diabetic Rats

Yu-Wen Cheng
College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan; Department of Internal Medicine, Lee's General Hospital, Miaoli, Taiwan
Ying-I Chen
College of Life Sciences, National Chung Hsing University, Taichung, Taiwan
Chung-Yuh Tzeng
Department of Orthopedics, Taichung Veterans General Hospital, Taichung, Taiwan
Chin-Hsien Chang
Department of Traditional Chinese Medicine, En Chu Kong Hospital, Taipei, Taiwan
Yu-Chen Lee
School of Chinese Medicine, China Medical University, Taichung, Taiwan
Hong-Chen Chen
College of Life Sciences, National Chung Hsing University, Taichung, Taiwan
Chin-Chun Tsai
Department of Traditional Chinese Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan
Tai-Hao Hsu
Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.); Department of Bioindustry Technology, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.); bDepartment of Food Science and Biotechnology, Da-Yeh University, Taiwan, R.O.C
Yiu-Kay Lai
College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan
Shih-Liang Chang
School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan

RÉSUMÉ

In our previous research, Cordyceps militaris (CM) had a hypoglycemic effect in normal rats. In this study we wanted to elucidate whether CM also had an effect on diabetic rats. Twelve rats with streptozotocin-induced diabetes were separated randomly into 2 groups. First, aqueous extracts of CM 10 mg/kg (CM group) or saline (control group) was fed to the rats; then the plasma glucose levels were assayed. Second, the signaling proteins IRS-1 and GLUT-4 collected from the muscle were detected. Finally, another 2 groups of rats were injected with atropine 0.1 mg/kg intraperitoneally just before the CM/saline feeding, and the assays mentioned above were repeated. Blood glucose decreased 7.2% in the CM group but only 1.5% in the control group (P < 0.05). The IRS-1 signal was 2.9-fold higher than actin in the CM group but only 0.8-fold higher in the control group (P < 0.005). In GLUT-4 signal, the difference was 1.7- vs. 0.6-fold, respectively, compared with actin (P < 0.05). However, atropine injection made CM-induced hypoglycemia or elevation of IRS-1 and GLUT-4 not significant. In conclusion, CM had a hypoglycemic effect in diabetic rats and atropine blocked it. Therefore, the cholinergic activation also was considered to be involved in the hypoglycemic effect of CM in rats with streptozotocin-induced diabetes.


Articles with similar content:

Serum Testosterone Levels in Statin Therapy for Patients with Diabetes and Hypertension
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Anuradha Argi, Jagannadha Rao Peela, Azhar Hussain, Aaren Vedangi, Shakila Srikumar, Ahmed M. Zakoko, Yupa Min , Dawoodi Fakruddin, Wahid M. El Sheriff, Abdalla Mohammed Jarrari, Mohammed G. Elfturi, Sara A. Shoaib, Laxmi Teja Peela, Avinash K. Rawal, Noah Mohammed Hamed Aljarari
Lack of Adaptive Response of Human Lymphocytes Exposed In Vivo to Low Doses of Ionizing Radiation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.23, 2004, issue 3
Gordana Joksic, Suzana Petrovic
Endothelial Monocyte-Activating Polypeptide-II Improves Diastolic Heart Function and Vascular Relaxation in Type-I Diabetes Mellitus
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 3
Alexander I. Kornelyuk, Georgiy G. Vorobyov, I. Y. Cherepaxa, Vadim F. Sagach, Nataliya A. Dorofeyeva
Fruiting Bodies of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes) Alleviate Diabetes-Associated Oxidative Stress
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 1
Chien-Hsing Lee, Wen-Tzu Wu, Tai-Hao Hsu, Hui-Chen Lo
Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 5
Chien-Hsing Lee, Tai-Hao Hsu, Hui-Chen Lo