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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Antiproliferative and Apoptotic Activities of the Medicinal Mushroom Phellinus rimosus (Agaricomycetes) on HCT116 Human Colorectal Carcinoma Cells

Volume 20, Numéro 10, 2018, pp. 935-945
DOI: 10.1615/IntJMedMushrooms.2018028343
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RÉSUMÉ

Phellinus rimosus is a host-specific wood-rotting polypore that has been reported to be used by some tribes in Kerala, India, for curing mumps. We isolated a novel polysaccharide-protein complex from Ph. rimosus (PPC-Pr) that possessed significant antitumor activity. In this study, we examined the antiproliferative and apoptotic properties of PPC-Pr using human colon cancer cell line HCT116 as a model system. HCT116 cells were cultured in the presence of PPC-Pr at various concentrations (100-1000 μg/mL) for 24-96 hours, and the percentage of cell viability was evaluated using a 3-(4-5 dimethylthiozol-2-yl) 2-5-diphenyl-tetrazolium bromide (MTT) assay. The results showed that PPC-Pr inhibited cell viability in a time- and concentration-dependent manner. The antiproliferative effect of PPC-Pr was associated with apoptosis on HCT116 cells. We analyzed the morphological changes in the PPC-Pr-treated HCT116 cells using fluorescent DNA-microscopy with 4',6-diamidino-2-phenylindole dihydrochloride hydrate (DAPI) and acridine orange-ethidium bromide (AO/EB) staining. With DAPI staining, the cells treated with PPC-Pr showed nuclear shrinkage and chromatin condensation. Apoptotic morphology in cellular bodies as well as chromatin condensation were also confirmed by AO/EB double staining. Oligonucleosomal DNA fragmentation in PPC-Pr-treated cells was evaluated using a comet assay. The comet assay showed that control cells had few nuclei with fragmented chromatin, whereas apoptotic nuclei were more frequent in PPC-Pr-treated cells. These investigations indicate that the polysaccharide-protein complex from Ph. rimosus possesses antiproliferative activity and induces marked apoptosis in tumor cells in vitro.

CITÉ PAR
  1. Yu Taihen, Zhong Shi, Sun Yuqing, Sun Haiyan, Chen Weiguo, Li Yougui, Zhu Jianxun, Lu Longxi, Huo Jinxi, Aqueous extracts of Sanghuangporus vaninii induce S‑phase arrest and apoptosis in human melanoma A375 cells, Oncology Letters, 22, 2, 2021. Crossref

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