Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024550
pages 1093-1099

Acute Toxicity Study and the In Vitro Cytotoxicity of a Black Lingzhi Medicinal Mushroom, Amauroderma rugosum (Agaricomycetes), from Malaysia

Shin Yee Fung
Medicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Nget Hong Tan
Medicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia
Boon Hong Kong
Medicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Sook Shien Lee
Medicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Yee Shin Tan
Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Vikineswary Sabaratnam
Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

RÉSUMÉ

Amauroderma rugosum is a wild medicinal mushroom also known as budak cendawan sawan. Members of the indigenous Malaysian Temuan community wear the fresh stipes as a necklace to prevent epileptic seizure and unremitting crying by babies. In our previous studies, A. rugosum exhibited significant antioxidant and anti-inflammatory activities. The aim of this study was to determine the toxicity (in the event that a stipe is accidentally bitten) and cytotoxicity of this mushroom on Sprague-Dawley rats and selected cell lines. A. rugosum was orally administered to test chemicals according to Organisation for Economic and Co-operation and Development guidelines (TG 425, adopted October 3, 2008). Blood samples were hematologically and biochemically analyzed and multiple tissue sections from each organ were examined using light microscopy. Cytotoxicity of various A. rugosum extracts was also determined against MCF-7 and A-549 cell lines. Our results showed that oral administration of a single dose of mycelial powder (2000 mg/kg) had no adverse effect on the growth rate or hematological and clinical biochemical parameters. Histological studies showed that the treatments did not induce any pathological changes in the organs of the tested animals. All the treated rats survived beyond the 14-day observation period. Methanol and cold and hot water extracts of the freeze-dried mycelial culture of A. rugosum exhibited no or little cytotoxic effect against the MCF-7 and A-549 cell lines.


Articles with similar content:

Lack of Adaptive Response of Human Lymphocytes Exposed In Vivo to Low Doses of Ionizing Radiation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.23, 2004, issue 3
Gordana Joksic, Suzana Petrovic
Radioprotective Effect of Carvacrol Against X-Radiation−Induced Cellular Damage in Cultured Human Peripheral Blood Lymphocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 3
Nisha Susan Thomas, Thayalan Kuppusamy, Nalini Namashivayam, Sivaranjani Arivalagan
Investigation of Antiproliferative Effect of Ether and Ethanol Extracts of Birch Polypore Medicinal Mushroom, Piptoporus betulinus (Bull.:Fr.) P. Karst. (Higher Basidiomycetes) In Vitro Grown Mycelium
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 6
Lucyna Kapka-Skrzypczak, Wojciech Rzeski, Jozef Kaczor, Katarzyna Walczak, Martyna Kandefer-Szerszen, Malgorzata Cyranka, Marcin Graz
Protective Effect of Alstonia scholaris Against Radiation-Induced Clastogenic and Biochemical Alterations in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
Pradeep Kumar Goyal, Swafiya Jahan
Optimization of Submerged Cultivation Conditions for Production of Big Cup Culinary-Medicinal Mushroom Clitocybe maxima (Agaricomycetes) Biomass with Significant Antioxidative and Antihyperlipidemic Activities
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 7
Peter Chi Keung Cheung, Shu-Hui Hu, Ker-Shew Chen, Jinn-Chyi Wang, Ming-Yi Liu, Sue-Joan Chang