Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Involvement of G2/M Cell Cycle Arrest and the Mitochondrial Pathway in Boletopsis leucomelaena (Pers.) Fayod (Agaricomycetideae) Lectin-Induced Apoptosis of Human Leukemia U937 Cells
RÉSUMÉ
Boletopsis leucomelaena lectin (BLL) is the first example of an apoptosis-inducing lectin of mushroom origin. Because it is not clear how apoptosis is induced by any lectin, we investigated the mechanism of apoptosis induction by BLL in human leukemic U937 cells. BLL was found to cause G2/M cell cycle arrest in U937 cells. This arrest was associated with the upregulation of p21/Waf1 expression. The observed decrease in the expression of Bcl-2 was compatible with the upregulated expression of p21/Waf1 and correlated to the enhanced release of cytochrome c from mitochondria to cytoplasm, leading to the activation of caspase-9 in BLL-treated U937 cells. These results provide the first example of a mushroom lectin whose apoptosis-inducing mechanism involves cell cycle arrest and the mitochondrial pathway.
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Kim Sung Phil, Kang Mi Young, Choi Yong Hee, Kim Jae Ho, Nam Seok Hyun, Friedman Mendel, Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells, Food & Function, 2, 6, 2011. Crossref
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Nosaka Sota, Miyazawa Mitsuo, Characterization of Volatile Components and Odor-active Compounds in the Oil of Edible Mushroom Boletopsis leucomelas, Journal of Oleo Science, 63, 6, 2014. Crossref
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Kaneko Akira, Tsukada Mariko, Fukai Miyuki, Suzuki Toshihiro, Nishio Kazuto, Miki Kazuhiko, Kinoshita Kaoru, Takahashi Kunio, Koyama Kiyotaka, KDR Kinase Inhibitor Isolated from the Mushroom Boletopsis leucomelas, Journal of Natural Products, 73, 5, 2010. Crossref
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Gondim Ana C.S., Romero-Canelón Isolda, Sousa Eduardo H.S., Blindauer Claudia A., Butler Jennifer S., Romero María J., Sanchez-Cano Carlos, Sousa Bruno L., Chaves Renata P., Nagano Celso S., Cavada Benildo S., Sadler Peter J., The potent anti-cancer activity of Dioclea lasiocarpa lectin, Journal of Inorganic Biochemistry, 175, 2017. Crossref