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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

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Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats

Volume 21, Numéro 4, 2019, pp. 401-411
DOI: 10.1615/IntJMedMushrooms.2019030320
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RÉSUMÉ

Recently, erinacine A-enriched Hericium erinaceus (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease. Despite promising results from animal models, there have been no reports on its toxicity after long-term consumption. Hence, the present study was designed to evaluate the safety of EAHE mycelia through a 13-week subchronic rodent feeding study. Following 13 weeks of EAHE mycelia feeding at dosages of 0, 875, 1750, and 2625 mg/kg body weight in both male and female Sprague-Dawley rats, findings revealed neither any mortalities nor noticeable toxicological effects in all the rats during the investigation period. Physiological parameters including body weight and feed consumption patterns were unaffected by EAHE mycelia administration. The hematological and biochemical parameters as well as histopathological studies revealed no significant differences between the treatment and control groups. Conclusively, the obtained results suggested that EAHE mycelia could be relatively unharmful when used over an extended period, supporting its safe use in food preparation.

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CITÉ PAR
  1. Li I-Chen, Chang Han-Hsin, Lin Chuan-Han, Chen Wan-Ping, Lu Tsung-Han, Lee Li-Ya, Chen Yu-Wen, Chen Yen-Po, Chen Chin-Chu, Lin David Pei-Cheng, Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study, Frontiers in Aging Neuroscience, 12, 2020. Crossref

  2. Limanaqi Fiona, Biagioni Francesca, Busceti Carla Letizia, Polzella Maico, Fabrizi Cinzia, Fornai Francesco, Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea, Antioxidants, 9, 3, 2020. Crossref

  3. Rai Sachchida Nand, Mishra Divya, Singh Payal, Vamanu Emanuel, Singh M.P., Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, 137, 2021. Crossref

  4. Khieokhajonkhet Anurak, Aeksiri Niran, Ratanasut Kumrop, Kannika Korntip, Suwannalers Piluntasoot, Tatsapong Pattaraporn, Inyawilert Wilasinee, Kaneko Gen, Effects of dietary Hericium erinaceus powder on growth, hematology, disease resistance, and expression of genes related immune response against thermal challenge of Nile tilapia (Oreochromis niloticus), Animal Feed Science and Technology, 290, 2022. Crossref

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