Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Medicinal Mushrooms
Facteur d'impact: 1.423 Facteur d'impact sur 5 ans: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018029348
pages 79-88

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Supplementation Alters Gut Microbiome and Corrects Dyslipidemia in Rats

Haseeb Anwar
Department of Physiology, Government College University, Faisalabad, Pakistan
Jan S. Suchodolski
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA
Muhammad Irfan Ullah
Department of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, Pakistan
Ghulam Hussain
Department of Physiology, Government College University, Faisalabad, Pakistan
Muhammad Z. Shabbir
Quality Control Laboratory, University of Veterinary and Animal Sciences, Lahore, Pakistan
Imtiaz Mustafa
Department of Physiology, Government College University, Faisalabad, Pakistan
Muhammad U. Sohail
Biomedical Research Center, Qatar University, Qatar


Recent interest in diet-induced modulation of the gut microbiome has led to research on the impact that dietary fibers can have on host health. Lentinus edodes mushroom-derived fibers may act as an appropriate substrate for gut microbe digestion and metabolism. The metabolites that gut microbes excrete can modulate host energy balance, gut absorption, appetite, and lipid metabolism. In the present study, we explored the dynamics of the gut microbiome of hypercholesterolemic rats supplemented with L. edodes. Wistar rats were offered a chow maintenance diet (CMD; CON group) or the same CMD ration with cholesterol (1.5% w/w) and cholic acid (0.5% w/w) added to induce hypercholesterolemia (day 1 to day 24). Hypercholesterolemic rats were subsequently offered either the same cholesterol-cholic acid diet (HC-CON group) or were supplemented with L. edodes (5% w/w; LE group) for 42 days (day 25 to day 66). At the end of the experiment, serum triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol concentrations were determined. Colon digesta were subjected to DNA extraction and subsequent 16S rRNA gene sequencing. Raw sequences were quality filtered and statistically analyzed using QIIME and LEfSe tools. Triglyceride concentrations were lower (P = 0.002) in the LE group than in the CON and HC-CON groups. Total cholesterol and LDL cholesterol concentrations were slightly decreased, whereas HDL cholesterol concentrations were increased by L. edodes supplementation compared with the HC-CON group. The gut microbiome of the LE group had higher species richness characterized by increased abundance of Clostridium and Bacteroides spp. Linear discriminant analysis identified bacterial clades that were statistically different among treatment groups. In conclusion, manipulation of gut microbiota through the administration of L. edodes could manage dyslipidemia.

Articles with similar content:

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Haseeb Anwar, Jaweria Nisar, Ghulam Hussain, Shazia Anwer Bukhari, Muhammad Naeem Faisal, Muhammad Irfan Ullah, Abdul Basit, Imtiaz Mustafa, Muhammad Umar Sohail
White Button Mushroom, Agaricus bisporus (Agaricomycetes), and a Probiotics Mixture Supplementation Correct Dyslipidemia without Influencing the Colon Microbiome Profile in Hypercholesterolemic Rats
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 3
Zahid Kamran, Haseeb Anwar, Farhan Asad, Aziz-ul-Rahman, Muhammad Umar Sohail, Muhammad Irfan Ullah, Hadi M. Yassine
Combined Administration of the White Button Mushroom Agaricus bisporus (Agaricomycetes) and Lactobacillus casei Modulated Immune-Related Gene Expression and Mucosal and Serum Immune Parameters in a Goldfish (Carassius auratus) Model
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 5
Shabnam Nejadmoghaddam, Seyed Hossein Hoseinifar, Maryam Dadar, Roghieh Safari
Effect of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Mycelium on Benzo[a]prene-Induced Early Alterations of the Respiratory Epithelium in the Hypercholesterolaemic Rats
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Suhaila Mohamed, Chow Chin Tong, Nor Aini B. Umar, Mohamed Mustapha Noordin, Yew Keong Choong
Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 3
Yitong Zheng, Hong-Yu Xu, Xin Xu, Zhenming Lu, Chengjian Yang, Zheng-Hong Xu, Chong Pang