Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis
RÉSUMÉ
This study investigated the anti-inflammatory activity of ethanol extracts of Hericium erinaceus in the inflammatory bowel disease (IBD) model. Twenty C57BL/6 mice were exposed to 2% (w/v) dextran sulfate sodium (DSS) in their drinking water for 7 d to induce acute intestinal inflammation. Orally administrated ethanol extract of H. erinaceus (HEEE) (250 mg/kg/d and 500 mg/kg/d body weight) could significantly (P < 0.05) improve body weight and colon length and decreased the intestinal bleeding of DSS-treated mice compared with DSS-treated mice not given HEEE. HEEE markedly reduced DSS-induced myeloperoxidase accumulation in colon tissues, attenuated histological change in the neutrophils and lymphocyte infiltration, and protected the mucosal epithelium. Mechanistically, HEEE ameliorated colitis not only by suppressing the production of inflammatory mediators including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in colon tissues but also by adjusting the production of nitric oxide, malondialdehyde, and superoxide dismutase in serum to suppress the oxidative stress. These results suggest that HEEE can be applied as a protective agent in the treatment of IBDs.
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Ren Yilin, Geng Yan, Du Yan, Li Wang, Lu Zhen-Ming, Xu Hong-Yu, Xu Guo-Hua, Shi Jin-Song, Xu Zheng-Hong, Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota, The Journal of Nutritional Biochemistry, 57, 2018. Crossref
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Wang Yalin, Ji Xingming, Yan Meilin, Chen Xue, Kang Mingzhu, Teng Liping, Wu Xiaotao, Chen Jinghua, Deng Chao, Protective effect and mechanism of polysaccharide from Dictyophora indusiata on dextran sodium sulfate-induced colitis in C57BL/6 mice, International Journal of Biological Macromolecules, 140, 2019. Crossref
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Jang Hyun-Jong, Kim Ji-Eun, Jeong Kyoung, Lim Sung, Kim Seong, Cho Kyung-Ok, The Neuroprotective Effect of Hericium erinaceus Extracts in Mouse Hippocampus after Pilocarpine-Induced Status Epilepticus, International Journal of Molecular Sciences, 20, 4, 2019. Crossref
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Bailly Christian, Gao Jin-Ming, Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities, Pharmacological Research, 159, 2020. Crossref
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Li Muxia, Luo Ting, Huang Yong, Su Jiyan, Li Dan, Chen Xiaohong, Zhang Yifan, Huang Longhua, Li Shunxian, Jiao Chunwei, Li Wenzhi, Xie Yizhen, Li Wende, Polysaccharide from Pycnoporus sanguineus ameliorates dextran sulfate sodium‐induced colitis via helper T cells repertoire modulation and autophagy suppression , Phytotherapy Research, 34, 10, 2020. Crossref
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Kamalian Aida, Asl Masoud Sohrabi, Dolatshahi Mahsa, Afshari Khashayar, Shamshiri Shiva, Roudsari Nazanin Momeni, Momtaz Saeideh, Rahimi Roja, Abdollahi Mohammad, Abdolghaffari Amir Hossein, Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways, World Journal of Gastroenterology, 26, 24, 2020. Crossref
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Yeh Chung‑Hsin , Sun Li‑Wei , Lai Chang‑Mei , Yeh Tzu‑Pei , Lin Jong‑Ni , Tsay Shiow‑Luan , Chen Chin‑Chu , Chen Wan‑Ping , Chen Chien‑Min , Tsai Ru‑Yin , Effect of ethanol extracts of Hericium�erinaceus mycelium on morphine‑induced microglial migration, Molecular Medicine Reports, 2019. Crossref
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Lv Guoying, Song Xiaoya, Zhang Zuofang, Protective Effect of the Ethanol Extract from <i>Hericium erinaceus</i> Against Ethanol-Induced Gastric Ulcers, Polish Journal of Food and Nutrition Sciences, 2021. Crossref
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Durmus Ali, Durmus Ilgim, Bender Omer, Karatepe Oguzhan, The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats, The Korean Journal of Internal Medicine, 36, Suppl 1, 2021. Crossref
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Fernandes Tito, Garrine Carmen, Ferrão Jorge, Bell Victoria, Varzakas Theodoros, Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa, Applied Sciences, 11, 9, 2021. Crossref
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Zhang Dongjing, Xiang Ming, Jiang Yun, Wu Fen, Chen Huaqun, Sun Min, Zhang Lingzhi, Du Xianfeng, Chen Lei, The Protective Effect of Polysaccharide SAFP from Sarcodon aspratus on Water Immersion and Restraint Stress-Induced Gastric Ulcer and Modulatory Effects on Gut Microbiota Dysbiosis, Foods, 11, 11, 2022. Crossref
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Anusiya G, Gowthama Prabu U, Yamini N V, Sivarajasekar N, Rambabu K, Bharath G, Banat Fawzi, A review of the therapeutic and biological effects of edible and wild mushrooms, Bioengineered, 12, 2, 2021. Crossref
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Khieokhajonkhet Anurak, Aeksiri Niran, Ratanasut Kumrop, Kannika Korntip, Suwannalers Piluntasoot, Tatsapong Pattaraporn, Inyawilert Wilasinee, Kaneko Gen, Effects of dietary Hericium erinaceus powder on growth, hematology, disease resistance, and expression of genes related immune response against thermal challenge of Nile tilapia (Oreochromis niloticus), Animal Feed Science and Technology, 290, 2022. Crossref
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Winder Mateusz, Bulska-Będkowska Weronika, Chudek Jerzy, The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology, Acta Pharmaceutica, 71, 1, 2021. Crossref
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Chi Jin Hua, Kim Young Ho, Sohn Dong Hwan, Seo Geom Seog, Lee Sung Hee, Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro, Biomedicine & Pharmacotherapy, 108, 2018. Crossref
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Zhang Jingsong, Feng Na, Liu Yangfang, Zhang Henan, Yang Yan, Liu Liping, Feng Jie, , 2022. Crossref