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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i5.60
pages 463-469

Influence of Navisporus floccosus (Higher Basidiomycetes) n-Hexane Extract on Arachidonate Metabolism in Vitro

Vivian Leliebre-Lara
Centre for Natural Product Studies, Faculty of Chemistry, University of Havana; Havana, Cuba
Eva-Maria Pferschy-Wenzig
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz; Graz, Austria
Ute Widowitz
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz; Graz, Austria
Sabine Ortmann
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz; Graz, Austria
Clara Nogueiras Lima
Centre for Natural Product Studies, Faculty of Chemistry, University of Havana; Havana, Cuba
Rudolf Bauer
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, 8010 Graz, Austria

RÉSUMÉ

In vitro anti-inflammatory activity of 4 extracts with different polarity from the basidiomycete Navisporus floccosus was evaluated by determination of the inhibition of prostaglandin E2 formation catalyzed by purified cyclooxygenase (COX)-1 and COX-2 enzymes, and of the inhibition of leukotriene (LT) B4 formation in human polymorphonuclear leukocytes. The n-hexane extract showed the highest activity in all 3 assays. Through analysis by gas chromatography coupled with mass spectrometry (GC-MS), 9 fatty acids and fatty acid esters were identified as the major constituents of this extract. As several of them also showed inhibitory activity in the COX and LTB4 formation assays, it can be assumed that the unsaturated as well as the saturated fatty acids, and maybe also the fatty acid esters, present in the extract synergistically contribute to its in vitro anti-inflammatory activity.


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