Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Oral Hypoglycemic Activity of Culinary-Medicinal Mushrooms Pleurotus ostreatus and P. cystidiosus (Higher Basidiomycetes) in Normal and Alloxan-Induced Diabetic Wistar Rats
RÉSUMÉ
This study investigates the oral hypoglycemic activity of Pleurotus ostreatus (P.o.) and P. cystidiosus (P.c.) mushrooms on normal and alloxan-induced diabetic Wistar rats. Different doses (250, 500, 750, 1000, and 1250 mg/kg/body weight) of suspensions of freeze-dried and powdered (SFDP) P.o. and P.c. were administered to normal rats, and postprandial serum glucose levels were measured. Optimal time of activity was investigated using the dose 500 mg/kg. Hypoglycemic effect of a single dose of SFDP P.o. and P.c. (500 mg/kg) were investigated using diabetic male and female rats at different stages of estrous cycle and compared with metformin and glibenclamide. Chronic hypoglycemic activity of SFDP P.o. and P.c. (500 mg/kg) was studied using serum glucose levels and glycosylated hemoglobin levels. Maximally effective dose of SFDP P.o. and P.c. was 500 mg/kg. The highest reduction in the serum glucose level was observed 120 minutes after administration of mushrooms. A single dose of P.o. and P.c. significantly (P < 0.05) reduced the serum glucose levels of male diabetic rats. The hypoglycemic activity in female rats was highest in proestrous stage. The hypoglycemic effect of P.o. and P.c. is comparable with metformin and glibenclamide. Daily single administrations of P.o. and P.c. to diabetic rats exert apparent control on the homeostasis of blood glucose. SFDP P.o. and P.c. possessed marked and significant oral hypoglycemic activity. This study suggests the consumption of P.o. and P.c. mushrooms might bring health benefits to mankind as it shows hypoglycemic activity in rats.
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Jayasuriya W. J. A. Banukie N., Wanigatunge Chandanie A., Fernando Gita H., Abeytunga D. Thusitha U., Suresh T. Sugandhika, Hypoglycaemic Activity of CulinaryPleurotus ostreatusandP.cystidiosusMushrooms in Healthy Volunteers and Type 2 Diabetic Patients on Diet Control and the Possible Mechanisms of Action, Phytotherapy Research, 29, 2, 2015. Crossref
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Kaneko Takaaki, Chihara Takeshi, Shimpo Kan, Beppu Hidehiko, Higashiguchi Takashi, Sonoda Shigeru, Inhibition of Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet by Pleurotus eryngii (Eringi) and Hypsizygus marmoreus (Bunashimeji), Asian Pacific Journal of Cancer Prevention, 16, 9, 2015. Crossref
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Zhang Jianjun, Meng Guangyuan, Zhang Chen, Lin Lin, Xu Nuo, Liu Min, Cui Fangyuan, Jia Le, The antioxidative effects of acidic-, alkalic-, and enzymatic-extractable mycelium zinc polysaccharides by Pleurotus djamor on liver and kidney of streptozocin-induced diabetic mice, BMC Complementary and Alternative Medicine, 15, 1, 2015. Crossref
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Morris Humberto J., Llauradó Gabriel, Beltrán Yaixa, Lebeque Yamila, Bermúdez Rosa C., García Nora, Gaime-Perraud Isabelle, Moukha Serge, The Use of Mushrooms in the Development of Functional Foods, Drugs, and Nutraceuticals, in Wild Plants, Mushrooms and Nuts, 2016. Crossref
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Dicks Lisa, Ellinger Sabine, Effect of the Intake of Oyster Mushrooms (Pleurotus ostreatus) on Cardiometabolic Parameters—A Systematic Review of Clinical Trials, Nutrients, 12, 4, 2020. Crossref
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Jayasuriya W. J. A. Banukie N., Handunnetti Shiroma M., Wanigatunge Chandanie A., Fernando Gita H., Abeytunga D. Thusitha U., Suresh T. Sugandhika, Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref
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da Costa Paola Quevedo, Paim Mariana Parron, dos Reis Eduardo Echer, Türck Patrick, Camassola Marli, Schenkel Paulo Cavalheiro, Beneficial effects of Pleurotus albidus supplementation on body weight and food intake in healthy C57BL/6 mice, Journal of Future Foods, 1, 1, 2021. Crossref
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González-Bonilla Adrián , Meneses María Eugenia, Pérez-Herrera Aleyda , Armengol-Álvarez David , Martínez-Carrera Daniel , Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico , International Journal of Medicinal Mushrooms, 24, 9, 2022. Crossref
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dos Reis Eduardo Echer, Schenkel Paulo Cavalheiro, Camassola Marli, Effects of bioactive compounds from Pleurotus mushrooms on COVID-19 risk factors associated with the cardiovascular system, Journal of Integrative Medicine, 20, 5, 2022. Crossref