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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.130
350 pages

Anti-MRSA Compounds from Hericium erinaceus (Bull.:Fr.) Pers.

Hirokazu Kawagishi
Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan; Graduate School of Agriculture, Shizuoka University, Shizuoka, Japan; and Graduate School of Science and Technology, Shizuoka University, Japan

RÉSUMÉ

Methicillin-resistant Staphylococcus aureus (MRSA) is currently one of the most prevalent pathogens in nosocomial infections. Because hospital-acquired MRSA strains exhibit resistance to many antibiotics and are transmitted from patient to patient via transiently colonized hands of hospital personnel, MRSA infections pose a serious problem for hospitalized patients.
We found that extracts of the fruiting bodies and the mycelia of Hericium erinaceus (Bull.:Fr.) Pers. exhibited anti-MRSA activity. Therefore, we tried to isolate the anti-MRSA compounds from the fungus.
Isolation of the active compounds was guided by anti-MRSA activity. The fungus was cultivated by shaking at 30 °C for 4 weeks. The culture was centrifuged, and the resulting residue was extracted with 85% ethanol, and the extract, after evaporating the solvent, was partitioned between chloroform and water and then ethyl acetate and water. Repeated silica gel chromatography and HPLC of the chloroform-soluble and ethyl-acetate–soluble parts gave five active compounds. The fruiting bodies of the fungus were also extracted with 85% ethanol, and the extract was concentrated and fractionated by solvent partitions between chloroform and water, and then ethyl acetate and water. Repeated silica gel chromatography and HPLC of the chloroform-soluble part gave an anti-MRSA compound.


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