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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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A Study of Pharmacological Components from Submerged Culture Mycelia of Phellinus linteus (Berk. et Curt.) Teng

Volume 7, Numéro 3, 2005, pp. 436-437
DOI: 10.1615/IntJMedMushrooms.v7.i3.760
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RÉSUMÉ

Phellinus linteus is apolypore of class Hymenomycetes and a heart-rot fungus occurring especially in groves of Morus bombycis Koidz. In Japan this fungus has been named Meshimakobu because it was found mainly in Meshima of the Danjo Islands in Nagasaki Prefecture. In Chinese medicine it has been called Souou and is used as a medicinal ingredient. About 30 years ago, certain pharmacological effects of this fungus were examined, and it was revealed that this fungus exhibited the highest antitumor activity among the Hymenomycetes mushrooms (Ikekawa et al., 1968). In this study, we found some biological activities of the mycelia extract and succeeded in isolation and structure-determination of the active principles in the extract (Nakamura et al., 2000, 2002). The results are as follows:

  • The scavenging activity of superoxide anion radicals of the extracts was detected. As a result, caffeic acid was isolated as an antioxidant (Nakamura et al., 2002). The IC50 of this principle was 3.05 μg/mL (16.9 μM). This was the first report in which caffeic acid was isolated from mushroom mycelia. It was proposed that caffeic acid may partly contribute to the pharmacological activity of Ph. Linteus.
  • The anti-allergic activity of the extracts was demonstrated by in vivo assay using NC/Nga/mice. Oral administration of mycelial extracts of Ph. Linteus exerted type-I allergy suppressive effects by inhibiting the production of serum IgE and inhibiting the formation of dermatitis-like skin lesions. Hot-water extracts of the mycelia was more active than the culture filtrates.
  • The antitumor activity of the extracts was examined by using Sarcoma 180/mice, p.o. As a result, all the fractions of Ph. Linteus mycelia showed antitumor activity in the solid tumors implanted in mice. The highest antitumor activity (81.2%) was observed in the protein/glucan complex obtained by the precipitation of 24% NaOH extract at pH 6.0. The protein/glucan complex consisted of 39.3% polysaccharide and 49.4% protein. Its 13C and 1H NMR data showed that the main glucan part of the complex was primarily α-1,3-glucan chains (Nakamura et al., 2004).
It was demonstrated that the mycelia component of Ph. Linteus showed useful activity for the treatment of allergic disease and cancer. These two diseases are recognized as very serious illnesses in Japan. The antioxidant activity (superoxide scavenging activity) of the mycelia component may contribute to keeping people’s health.

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