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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.650
423 pages

The Receptor for β-Glucan of Ganoderma lucidum (W.Curt.:Fr.) Lloyd in Immune Cells

Ha Won Kim
Department of Life Sciences, University of Seoul Dongdaemun-gu, Jennong-dong 90, Seoul 130-743, South Korea
Byong Kak Kim
College of Pharmacy Seoul National University Seoul 151-724; and Department of Life Science, University of Seoul, Seoul 130-743, South Korea

RÉSUMÉ

The mechanisms on how polysaccharides of medicinal mushrooms can be absorbed and used in the potentiation of immunity in human bodies has not been elucidated until recently. In 2001, dectin-1 was identified as a β-glucan receptor, which is calcium dependent and whose gene is located on mouse chromosome 6 and human chromosome 12. The dectin-1 mRNA is highly expressed in dendritic cells. Dendritic cells and macrophages have pattern recognition molecules for binding β-glucan. Dectin-1 was also found in murine organs, spleen, thymus, lung, and intestines. Treatment of macrophages with β-glucan of Ganoderma lucidum (GLG) resulted in an increase of IL-6 and TNF-α in the presence of LPS. But GLG alone did not increase IL-6 or TNF-α. The results suggest that dectin-1 may cooperate with CD-14 to activate signal transduction, which is important in immune responses.


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